7TL8A

1.95a resolution structure of independent phosphoglycerate mutase from s. aureus in complex with a macrocyclic peptide inhibitor (sa-d3)
Total Genus 184
50100150200250300350400450050100150
Genus TraceResidueGenus

The genus trace: a function that shows values of genus (vertical axis) for subchains spanned between the first residue, and all other residues (shown on horizontal axis). The number of the latter residue and the genus of a given subchain are shown interactively.

Total Genus
184
sequence length
505
structure length
488
Chain Sequence
MAKKPTALIILDGFANRESEHGNAVKLANKPNFDRYYNKYPTTQIEASGLDVGLPEGQMGNSEVGHMNIGAGRIVYQSLTRINKSIEDGDFFENDVLNNAIAHVNSHDLHIFGLLSDGGVHSHYKHLFALLELAKKQGVEKVYVHAFLDGRDVDQKSALKYIEETEAKFNELGIGQFASVSGRYYAMDRDKRWEREEKAYNAINFDAPTYATAKEGVEASYNEGLTDEFVVPFIVENQNDGVVIFYNFRPDRAAQLSEIFANQVKDLFYATFTKYNDNIDAAIVFEKVDLNNTIGEIAQNNNLTQLRIAETEKYPHVTYFMSGGRNEEFKGERRRLIDSPKVATYDLKPEMSAYEVKDALLEELNKGDLDLIILNFANPDMVGHSGMLEPTIKAIEAVDECLGEVVDKILDMDGYAIITADHGNSDQVLTDDDQPMTTHTTNPVPVIVTKEGVTLRETGRLGDLAPTLLDLLNVEQPEDMTGESLIKH
50100150200250300350400450400300200100
050100150Genus Matrix

The genus matrix. At position (x,y) a genus value for a subchain spanned between x’th and y’th residue is shown. Values of the genus are represented by color, according to the scale given on the right.

Structure visualization

After clicking on a point (x,y) in the genus matrix above, a subchain from x to y is shown in color.

Chord Diagram
AH3 (62-71)TIV1 (11-14)AH12 (311-318)EMPTYTIV6 (440-443)TII1 (20-23)S14 (432-437)AH16 (405-429)AH1 (24-27)TI6 (447-450)S2 (42-45)TI5 (441-444)3H1 (49-52)TII2 (55-58)AH14 (369-383)TVIII2 (288-291)AH4 (78-88)AH6 (126-139)3H2 (90-93)AH5 (95-107)AH11 (261-270)S4 (145-150)S3 (112-116)AH7 (159-174)S5 (178-184)TI1 (121-124)TII3 (238-241)TIV2 (151-154)TVIII1 (156-159)TIV3 (152-155)3H3 (230-232)AH8 (185-189)S8 (252-253)S6 (212-213)TI2 (257-260)TIV5 (281-284)S10 (299-300)3H4 (328-330)S11 (322-327)AH13 (331-335)TI4 (365-368)3H5 (337-339)S12 (349-354)TII4 (346-349)AH15 (394-401)3H6 (362-364)TVIII3 (359-362)S13 (388-393)TVIII4 (442-445)S15 (461-466)AH17 (481-489)AH2 (31-39)AH9 (195-205)AH10 (216-226)S16 (471-472)TII5 (467-470)3H7 (478-480)S7 (236-238)S1 (6-11)Updating...
connected with : NaN
publication title Serum-Stable and Selective Backbone-N-Methylated Cyclic Peptides That Inhibit Prokaryotic Glycolytic Mutases.
pubmed doi rcsb
molecule keywords 2,3-bisphosphoglycerate-independent phosphoglycerate mutase
molecule tags Isomerase/inhibitor
source organism Staphylococcus aureus
total genus 184
structure length 488
sequence length 505
ec nomenclature ec 5.4.2.12: phosphoglycerate mutase (2,3-diphosphoglycerate-independent).
pdb deposition date 2022-01-18
Image from the rcsb pdb (www.rcsb.org)
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