7AWEM

Human immunoproteasome 20s particle in complex with [(1r)-2-(1-benzofuran-3-yl)-1-{[(1s,2r,4r)-7-oxabicyclo[2.2.1]heptan-2-yl]formamido}ethyl]boronic acid
Total Genus 64
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The genus trace: a function that shows values of genus (vertical axis) for subchains spanned between the first residue, and all other residues (shown on horizontal axis). The number of the latter residue and the genus of a given subchain are shown interactively.

Total Genus
64
sequence length
213
structure length
213
Chain Sequence
RFSPYVFNGGTILAIAGEDFAIVASDTRLSEGFSIHTRDSPKCYKLTDKTVIGCSGFHGDCLTLTKIIEARLKMYKHSNNKAMTTGAIAAMLSTILYSRRFFPYYVYNIIGGLDEEGKGAVYSFDPVGSYQRDSFKAGGSASAMLQPLLDNQVGFKNMQNVEHVPLSLDRAMRLVKDVFISAAERDVYTGDALRICIVTKEGIREETVSLRKD
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The genus matrix. At position (x,y) a genus value for a subchain spanned between x’th and y’th residue is shown. Values of the genus are represented by color, according to the scale given on the right.

Structure visualization

After clicking on a point (x,y) in the genus matrix above, a subchain from x to y is shown in color.

Chord Diagram
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publication title M3258 is a selective inhibitor of the immunoproteasome subunit LMP7 ( beta 5i) delivering efficacy in multiple myeloma models.
pubmed doi rcsb
molecule tags Immune system
molecule keywords Proteasome subunit alpha type-6
total genus 64
structure length 213
sequence length 213
chains with identical sequence a
ec nomenclature ec 3.4.25.1: Proteasome endopeptidase complex.
pdb deposition date 2020-11-06

pfam database annotations

chain Pfam Accession Code Pfam Family Identifier Pfam Description
M PF00227 Proteasome Proteasome subunit
Image from the rcsb pdb (www.rcsb.org)
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similar chains in the Genus database (?% sequence similarity)
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similar chains in the pdb database (?% sequence similarity)

 
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