7BC4B

Cryo-em structure of fatty acid synthase (fas) from pichia pastoris
Total Genus 443
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The genus trace: a function that shows values of genus (vertical axis) for subchains spanned between the first residue, and all other residues (shown on horizontal axis). The number of the latter residue and the genus of a given subchain are shown interactively.

Total Genus
443
sequence length
2054
structure length
2054
Chain Sequence
RPLVLNHGSIESTILIPTTEYHFYQTLLEGFRKSLPQVTEGFADDDEPSSKAELLMKFLGYIVQSGVSNQQEQLAAAKLVLNEFESRFLQGLNLHSYAAILLKSETFPTTLLKIKENLIKNYYLGRALVYLPGQRGLVYPPSALLNAGKSGSAQIYAIFGGQGNTDDYFEELRDIYHIYQGLVSDFVTKAQLKLQELIRTTPETDRIYTQGLDLINWLENKDKTPDQQQLLSIPMSCPLICVIQLCHYIVTCRILGITPGQLRDSLKGTTGHSQGLVTAVVVSSADSWESFEKLALQAVEFMFYIGVRGLQTYPNTSLPPSIVQDSEENAEGTPSPMLSVRDLSYDQLVKFVNETNQHLPEAKHIDISLINGPRNVVLTGPPQSLYGLNLNLRKAKAPSGLDQARIPFSERKLRFSNRFLPIMSPFHSHLLSPSTEKIVADLKKAGVEFSQSSMKLPVFDTYDGKDLRSYSGSIAARLVECITKLRVNWELSTEFNSTHVLDFGPGGASGLGVLTHRNKEGTGSRVIVAGVLDAESEDSEFGYKQEIFESNEKAIKYAPNWLKEYKPKLVKTSAGKIFVDTKFSRLLGRAPLMVPGMTPTTVSPDFVAATLNAGFHTEIAGGGYFAPSIMKAALQRVIDQVTPGTGVGINLIYVNPRMLQWGIPMIKELREQGFPIQSLSIGAGVPSLEVATEYIETLGLAHLGLKPGSIDAVNQVITIAKAHPNFPIVLQWTGGRGGGHHSFEDFHQPILQMYSKIRKCKNIILIAGSGFGSAEDTYPYLTGSWSHQFSYPSMPFDGVLFGSRVMTAKEAKTSPAAKQAIADCTGVDNSQWENTYKKPTGGIITVRSEMGEPIHKIATRGVMLWKELDDTIFTLPKNKMLEAIAKKKDYIIKKLNADYQKPWFAKNEKGTCDLEDMTYKQIAERLVELMYVRKSQRWIDVTLRNFTGKFLRRIEERFATKVGTISLIQNFSQLEEPEKAIDSVFKAYPEAASQLINEEDCDWFLLEAQSPTQKPVPFIPVLDERFEFFFKKDSLWQSEDLEAVVGEDVQRTCILHGPVAAQFSNKVDEPIKDILENIHKGHIKSLVKEVYNGDESKIPVVEYFSSVDSFSDTAIEGVKIERSRNTETFTVTSGNVDNQQWFDLLAGKELSWRRAFITAARLVQGTNFVSNPAHSVLAPSKDLVVKIENGSDAKKTVLTAFQRVRGKYVPAVSLKSIGDLKIKLELIETRTADKSAVALELFYNYKPTDGFAPILEVMEGRNTSIKNFYWKLWFGSSVPVDLDFDANKPISGGEASVSSQAIAEFTHAVGNSCEDFVPRAGRPQLAPMDFAIVLGWKAIMKAIFPKTVDGDILKLVHLSNGYKMFPGADPLKKGDVVSTVAHIRSVVNGETGKTVEVVGVISRDGKPVLEVNSQFFYRGKYQDFGNSFKKTTETPVQVAFKSAKDIAVLKSKEWFHLEKDIDLLNQTLTFRCESYVKFKSSTVFASVKTTGQALLELPSKEIIQVAEINYESGSSYGNPVLDYLTRHGSTIEQPIMFENAIPLAQGTELTSKAPGTNETYAAVSGDYNPIHVNKVFASYANLPGTITHGMYSSAAVRALVEQWAAQNVATRVRAFKADFVGMVLPNDELVTHLEHVGMINGRKIIKVETKKVETEEVVLIGEAEIEQPVSTFVFTGQGSQEQGMGMDLYNSSEVAKSVWDRADVHFINNYGFSILDIVKNNPTELTVHFGGAKGRSIRNNYISMMFETVAADGQLKSEKIFKEINEDTISFTFKSPTGLLSATQFTQPALTLMEKASFEDMKSKGLVPSESMFAGHSLGEYSALTSLGDVMPIESLVDVVFYRGMTMQVAVPRDEQGRSNYGMIAVNPSRVSSTFNDSALRFVVEHIAQQTGWLLEIVNYNVENTQYVAAGDLRGLDTLSNVLNVFKIQKIDIVKLQETISLDEVKVHLSEIVDEVSKKSSSKPQPIDLERGFACIPLKGISVPFHSSYLRSGVKPFQTFLCKKIPKSAVKPANLIGKYIPNLTAKPFQLTKEYFEDVYELTKSEKIKHILDHW
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The genus matrix. At position (x,y) a genus value for a subchain spanned between x’th and y’th residue is shown. Values of the genus are represented by color, according to the scale given on the right.

Structure visualization

After clicking on a point (x,y) in the genus matrix above, a subchain from x to y is shown in color.

publication title Structural insight into Pichia pastoris fatty acid synthase.
pubmed doi rcsb
molecule tags Biosynthetic protein
molecule keywords Fatty acid synthase subunit alpha
total genus 443
structure length 2054
sequence length 2054
ec nomenclature ec 1.3.1.9: Enoyl-[acyl-carrier-protein] reductase (NADH).
pdb deposition date 2020-12-18

pfam database annotations

chain Pfam Accession Code Pfam Family Identifier Pfam Description
B PF00698 Acyl_transf_1 Acyl transferase domain
B PF01575 MaoC_dehydratas MaoC like domain
B PF08354 DUF1729 Domain of unknown function (DUF1729)
B PF13452 MaoC_dehydrat_N N-terminal half of MaoC dehydratase
B PF16073 SAT Starter unit:ACP transacylase in aflatoxin biosynthesis
B PF17828 FAS_N N-terminal domain in fatty acid synthase subunit beta
B PF17951 FAS_meander Fatty acid synthase meander beta sheet domain
Image from the rcsb pdb (www.rcsb.org)
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similar chains in the Genus database (?% sequence similarity)
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similar chains in the pdb database (?% sequence similarity)

 
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