7CD9A

Crystal structure of setdb1 tudor domain in complexed with compound 6
Total Genus 57
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The genus trace: a function that shows values of genus (vertical axis) for subchains spanned between the first residue, and all other residues (shown on horizontal axis). The number of the latter residue and the genus of a given subchain are shown interactively.

Total Genus
57
sequence length
215
structure length
215
Chain Sequence
ELSKDGDLIVSMRILGKKRTKTWHKGTLIAIQTVGPGKKYKVKFDNKGKSLLSGNHIAYDYHPPADKLYVGSRVVAKYKDGNQVWLYAGIVAETPNVKNKLRFLIFFDDGYASYVTQSELYPICRPLKKTWEDIEDISCRDFIEEYVTAYPNRPMVLLKSGQLIKTEWEGTWWKSRVEEVDGSLVRILFLDDKRCEWIYRGSTRLEPMFSMKTSS
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The genus matrix. At position (x,y) a genus value for a subchain spanned between x’th and y’th residue is shown. Values of the genus are represented by color, according to the scale given on the right.

Structure visualization

After clicking on a point (x,y) in the genus matrix above, a subchain from x to y is shown in color.

Chord Diagram
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molecule tags Transferase
molecule keywords Histone-lysine N-methyltransferase SETDB1
publication title Structure-Guided Discovery of a Potent and Selective Cell-Active Inhibitor of SETDB1 Tudor Domain.
doi rcsb
source organism Homo sapiens
total genus 57
structure length 215
sequence length 215
chains with identical sequence B
ec nomenclature ec 2.1.1.366: [Histone H3]-N(6),N(6)-dimethyl-lysine(9) N-methyltransferase.
pdb deposition date 2020-06-19

pfam database annotations

chain Pfam Accession Code Pfam Family Identifier Pfam Description
A PF18300 DUF5604 Domain of unknown function (DUF5604)
A PF18358 Tudor_4 Histone methyltransferase Tudor domain
A PF18359 Tudor_5 Histone methyltransferase Tudor domain 1
Image from the rcsb pdb (www.rcsb.org)
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similar chains in the Genus database (?% sequence similarity)
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similar chains in the pdb database (?% sequence similarity)

 
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