The genus trace: a function that shows values of genus (vertical axis) for subchains spanned between the first residue, and all other residues (shown on horizontal axis). The number of the latter residue and the genus of a given subchain are shown interactively.
Total Genus |
446
|
sequence length |
2157
|
structure length |
1937
|
Chain Sequence |
DEYVQELKGLIRKHIPERCEFGHQKVTFLSQVHPSPLLTEGFKLLSSLVELESCEAHACQANTDQRFVDVILSDNGILCPTLPKVIPDGFKLTGKTLILLETFVRVNPDEFEKKWKADMSKLLNLKHDLQKSGVTLVPIVDGRSNYNNRFVADWVIERIRWLLIEILKASKSEDQEYQRLIHSLSNVKLENLEHLKRNSLDYDERLNESLFIGLKGDIRESTVREELIKLKLWFKDEVFSKGLGKFKLTDRRELLESLSSLGAHLDSDVSSCPFCNNKLMEIVYNVTFSCVERSNIEKHYLSVLSLCNKIKGLKVFNTRRNTLLFLDLIMVNLMVDISDSCQDAIESLRKSGLIVGQMVMLVNDRVLDILEAVKLIRKKIGTNPNWVKNCSKILERSHPEIWHHLSTLIKQPDFNSLISIAQHLVSDRPIMRYSKICRHKLFQEMSSFEQMRLFKTLSSISLSLINSMKTSFSSRLLVNEFGNVRLRECYAQRFYLAESLVGFLFYQKTGERSRCYSVYLSDNGVMSEQGSFYCDPKRFFLPVFSDEVLAGMCEEMTSWLDFDTGLMNDTGPILRLLVLAILCSPSKRNQTFLQGLRYFLMAFANQIHHIDLTSKLVVECKSSSEVVVQRLAVGLFIRLLSGESDASLFFSRRFKYLLNVSYLCHLITKETPDRLTDQIKCFEKFIEPKVKFGCAVVNPSLNGKLTVDQEDIMINGLKKFFSKSLRDTEDVQTPGVCKELLNYCVSLFNRGKLKVSGELKNNPFRIPKLDELGNILSTYDKEKLVSACVSSMAERFKNLDPDSTDYLILKNLTTQEELSLMYEALTEEQVESFNEIKHDVQVALAKMADVSLHEVKDFDPDVLPPEVYKELCDAVYKSSEKCNFFLEGVLDVCPLGLLLKNLTTSSYVDEEYFMCFKYLLIQGHFDQFTNAALRNLCFYSEDSPTEFTSISSNSGNLKFGLSYKEQVGSNRELYVGDLNTKLMTRLVEDFSEAVGNSMKYTCLNSEKEFERAICDMKMAVNNGDLSCSYDHSKWGPTMSPALFLALLQMLELRTPVDRSKIDLDSVKSILKWHLHKVVEVPINVAEAYCIGSTSLSEEFFHQTMQLNGQIPSHIMSVLDMGQGILHNTSDLYGLITEQFLCYALDLLYDVIPVSYTSSDDQITLIKTPSDAAEWLEMICFHEFLSSKLNKFVSPKSVIGTFVAEFKSRFFVMGEETPLLTKFVAAALHNVKCKTPTQLSETIDTICDQCIANGVSTKIVTRISKRVNQLIRYSGYGETPFGAIEDQDVKDWVDGSRGYRLQRKIEAIFHDDKETSFIRNCARKVFNDIKRGRIFEENLINLIGRGGDEALTGFLQYAGCSEQEVNRVLNYRWVNLSSFGDLRLVLRTKLMTVPTLIKTLQSKLSRQSSVASGFIGFCKSMGSKCVRDGGFLYIKEVYSGVSACTCEICALKPKIIYCNNSLNKVSQFSKPILWDYFSLVLTNACELGEWVFSTVKEPQNNQNFFWAVKPKVVRQIEDQLGMNHVLQSIRRNYPVLFDEHLTPFMNDLQVSRTMDSGRLKFLDVCIALDMMNENLGIISHLLKTRDNSVYIVKQSDCALAHIRQSSYTDWELGLSPQQICTNFKTQLVLSSMVNPLVLSTSCLKSFFWFNEVLELEDDSQIELAELTDFALMVKNQNVSRAMFVEDIAMGYVVSNFEGVRISLSNVMVDGVQLPPQDIGELFGLKAGLVVQIDHVRMSTKFKLKRKMVYSFSLECIMDVGEIQNKEVILKVVAVDQSVSGSGGNHMLLDGVSVVASLPLFTGQASFDLAAMLIESNLAGSNDNFLMRNVTLDLGGFSPELSDKYSYRLSGPENQEDPLVLKDGAFYVGGERLSTYKVEFTGDLVVKALGALEDDESVVSMLHQLWPYLKATSQVILFQQEDFTIVHDLYKKQLTKSIE
|
The genus matrix. At position (x,y) a genus value for a subchain spanned between x’th and y’th residue is shown. Values of the genus are represented by color, according to the scale given on the right.
After clicking on a point (x,y) in the genus matrix above, a subchain from x to y is shown in color.
| publication title |
Cryo-EM structures of Lassa and Machupo virus polymerases complexed with cognate regulatory Z proteins identify targets for antivirals.
rcsb |
| molecule tags |
Viral protein
|
| source organism |
Machupo mammarenavirus
|
| molecule keywords |
RNA-directed RNA polymerase L
|
| total genus |
446
|
| structure length |
1937
|
| sequence length |
2157
|
| chains with identical sequence |
C
|
| ec nomenclature |
ec
2.7.7.48: RNA-directed RNA polymerase. |
| pdb deposition date | 2021-04-09 |
| chain | Pfam Accession Code | Pfam Family Identifier | Pfam Description |
|---|---|---|---|
| A | PF06317 | Arena_RNA_pol | Arenavirus RNA polymerase |
| A | PF17296 | ArenaCapSnatch | Arenavirus cap snatching domain |
Image from the rcsb pdb (www.rcsb.org)
#similar chains in the Genus database (?% sequence similarity) ...loading similar chains, please wait... #similar chains, but unknotted ...loading similar chains, please wait... #similar chains in the pdb database (?% sequence similarity) ...loading similar chains, please wait...
