7ENCDA

Tfiid-based pic-mediator holo-complex in fully-assembled state (hpic-med)
Total Genus 120
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The genus trace: a function that shows values of genus (vertical axis) for subchains spanned between the first residue, and all other residues (shown on horizontal axis). The number of the latter residue and the genus of a given subchain are shown interactively.

Total Genus
120
sequence length
865
structure length
550
Chain Sequence
WRYGPARLWYDMLGVPEDDLLADENFLMVTQLHWEDDIIWDGEPWYSIFPIDNEDLVYGRWEDNIIWDAQAMPRLLEPPVLTLDPNDENLILPWNLSNDEYYYPKIIQHSIPAVELRQPFFPTHMGPIKLRQFHRPPLKKYSFGALSQPGPHSVQPLLKHIKKKAKMREQERQASGGGEMFFMRTPQDLTGKDGDLILAEYSEENGPLMMQVGMATKIKNYYKRKPGKDPGAPDCKYGETVYCHTSPFLGSLHPGQLLQAFENNLFRAPIYLHKMPETDFLIIRTRQGYYIRELVDIFVVGQQCPLFEVPGPNSKRANTHIRDFLQVFIYRLFWKSKDRPRRIRMEDIKKAFPSHSESSIRKRLKLCADFKRTGMDSNWWVLKSDFRLPTEEEIRAMVSPEQCCAYYSMIAAEQRLKDAGDDEVRTAPWNTTRAFIAAMKGKCLLEVTGVADPTGCGEGFSYVKIPNKRFSVAEHQERYKEECQRIFDLQNKVLSSTEVLSTDSATGRCLKIYRTFRDEEGKEYVRCETVRKPAVIDAYVRIRTTKDEEF
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The genus matrix. At position (x,y) a genus value for a subchain spanned between x’th and y’th residue is shown. Values of the genus are represented by color, according to the scale given on the right.

Structure visualization

After clicking on a point (x,y) in the genus matrix above, a subchain from x to y is shown in color.

publication title Structures of the human Mediator and Mediator-bound preinitiation complex.
pubmed doi rcsb
molecule tags Transcription
source organism Homo sapiens
molecule keywords Mediator of RNA polymerase II transcription subunit 1
total genus 120
structure length 550
sequence length 865
ec nomenclature ec 2.3.1.48: Histone acetyltransferase.
pdb deposition date 2021-04-16

pfam database annotations

chain Pfam Accession Code Pfam Family Identifier Pfam Description
DA PF00439 Bromodomain Bromodomain
DA PF09247 TBP-binding TATA box-binding protein binding
DA PF12157 DUF3591 Protein of unknown function (DUF3591)
DA PF15288 zf-CCHC_6 Zinc knuckle
Image from the rcsb pdb (www.rcsb.org)
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similar chains in the Genus database (?% sequence similarity)
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similar chains in the pdb database (?% sequence similarity)

 
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#similar chains, but unknotted
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