7EU8A

Structure of the human glun1-glun2b nmda receptor in complex with s-ketamine,glycine and glutamate
Total Genus 127
100200300400500600700020406080100120
Genus TraceResidueGenus

The genus trace: a function that shows values of genus (vertical axis) for subchains spanned between the first residue, and all other residues (shown on horizontal axis). The number of the latter residue and the genus of a given subchain are shown interactively.

Total Genus
127
sequence length
814
structure length
761
Chain Sequence
NIGAVLSTRKHEQMFREAVNQANKRIQLNATSVTHKPNAIQMALSVCEDLISSQVYAILVSHPPTPNDHFTPTPVSYTAGFYRIPVLGLTTRMSIYSDKSIHLSFLRTVPPYSHQSSVWFEMMRVYSWNHIILLVSDDHEGRAAQKRLETLLEESKAEKVLQFDPGTKNVTALLMEAKELEARVIILSASEDDAATVYRAAAMLNMTGSGYVWLVGEREISGNALRYAPDGILGLQLINGKNESAHISDAVGVVAQAVHELLEKENITDPPRGCVGNTNIWKTGPLFKRVLMSSKYADGVTGRVEFNEDGDRKFANYSIMNLQNRKLVQVGIYNGTHVIPNDRKIIWPGGETEKPRGYQMSTRLKIVTIHQEPFVYVKPTLSDGTCKEEFTVNGDPVKKVICTGPNDTSPGSPRHTVPQCCYGFCIDLLIKLARTMNFTYEVHLVADGKFGTQERKEWNGMMGELLSGQADMIVAPLTINNERAQYIEFSKPFKYQGLTILVKKEDSFMQPFQSTLWLLVGLSVHVVAVMLYLLDRLSSAMWFSWGVLLNSGSFSARILGMVWAGFAMIIVASYTANLAAFLVLDRPEERITGINDPRLRNPSDKFIYATVKQSSVDIYFRRQVELSTMYRHMEKHNYESAAEAIQAVRDNKLHAFIWDSAVLEFEASQKCDLVTTGELFFRSGFGIGMRKDSPWKQNVSLSILKSHENGFMEDLDKTWVRYQECDTLTFENMAGVFMLVAGGIVAGIFLIFIEIAYKRHK
100200300400500600700700600500400300200100
020406080100120Genus Matrix

The genus matrix. At position (x,y) a genus value for a subchain spanned between x’th and y’th residue is shown. Values of the genus are represented by color, according to the scale given on the right.

Structure visualization

After clicking on a point (x,y) in the genus matrix above, a subchain from x to y is shown in color.

Chord Diagram
AH2 (71-85)EMPTYTIV2 (100-103)TIV1 (97-100)AH4 (126-131)AH6 (171-184)TIV6 (184-189)TIV4 (134-137)S2 (137-139)TIV5 (139-142)TI1 (143-146)AH5 (148-158)S7 (350-357)TIV7 (185-190)TVIII1 (201-204)AH7 (205-214)S4 (218-222)TVIII2 (216-219)TI2 (250-253)TI3 (251-254)AH9 (256-261)AH10 (279-297)S6 (266-271)TIV11 (298-301)TVIII4 (305-308)TI6 (307-310)TIV12 (308-311)AH11 (317-327)TI7 (333-336)S13 (473-477)S8 (360-368)TIV15 (367-370)TIV16 (368-371)TVIII5 (375-378)TI9 (381-384)S9 (397-401)TI10 (405-408)TI11 (415-418)S11 (434-437)TI13 (439-442)TIV18 (441-444)AH12 (458-470)S12 (452-457)S14 (486-488)AH17 (688-694)TIV20 (487-496)S15 (497-499)TIV26 (660-663)3H1 (501-505)AH15 (631-656)TI16 (522-525)TIV23 (520-523)TI15 (521-524)TI17 (553-556)TII'1 (555-558)AH14 (604-612)TI18 (612-615)TI19 (613-616)TI20 (627-630)TIV25 (626-629)TII'2 (665-668)TVIII8 (662-665)TI21 (666-669)AH19 (714-723)AH16 (670-673)TI23 (696-699)TVIII9 (694-697)TI25 (707-710)TIV28 (706-709)S17 (728-730)AH20 (733-743)S18 (746-759)AH1 (36-52)TIV3 (120-123)S1 (118-120)AH8 (225-238)O3 (431-433)TI12 (425-428)TI14 (479-482)TI22 (676-679)TIV24 (524-527)AH18 (700-705)S5 (247-249)AH13 (560-582)AH3 (104-113)TIV27 (684-687)S16 (532-543)Updating...
connected with : NaN
molecule tags Membrane protein
source organism Homo sapiens
publication title Structural basis of ketamine action on human NMDA receptors.
pubmed doi rcsb
molecule keywords Glutamate receptor ionotropic, NMDA 1
total genus 127
structure length 761
sequence length 814
chains with identical sequence C
ec nomenclature
pdb deposition date 2021-05-16

pfam database annotations

chain Pfam Accession Code Pfam Family Identifier Pfam Description
A PF00060 Lig_chan Ligand-gated ion channel
A PF01094 ANF_receptor Receptor family ligand binding region
A PF10613 Lig_chan-Glu_bd Ligated ion channel L-glutamate- and glycine-binding site
Image from the rcsb pdb (www.rcsb.org)
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