7JTPK

Crystal structure of protac ms67 in complex with the wd repeat-containing protein 5 and pvhl:elonginc:elonginb
Total Genus 25
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The genus trace: a function that shows values of genus (vertical axis) for subchains spanned between the first residue, and all other residues (shown on horizontal axis). The number of the latter residue and the genus of a given subchain are shown interactively.

Total Genus
25
sequence length
96
structure length
85
Chain Sequence
MYVKLISSDGHEFIVKREHALTSGTIKAMLNEVNFREIPSHVLSKVCMYFTYKVRYTNSSTEIPEFPIAPEIALELLMAANFLDC
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The genus matrix. At position (x,y) a genus value for a subchain spanned between x’th and y’th residue is shown. Values of the genus are represented by color, according to the scale given on the right.

Structure visualization

After clicking on a point (x,y) in the genus matrix above, a subchain from x to y is shown in color.

Chord Diagram
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publication title A selective WDR5 degrader inhibits acute myeloid leukemia in patient-derived mouse models.
pubmed doi rcsb
molecule tags Protein binding
source organism Homo sapiens
molecule keywords Elongin-B
total genus 25
structure length 85
sequence length 96
ec nomenclature
pdb deposition date 2020-08-18

pfam database annotations

chain Pfam Accession Code Pfam Family Identifier Pfam Description
K PF03931 Skp1_POZ Skp1 family, tetramerisation domain
Image from the rcsb pdb (www.rcsb.org)
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similar chains in the Genus database (?% sequence similarity)
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similar chains in the pdb database (?% sequence similarity)

 
#similar chains in the Genus database (?% sequence similarity)
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#similar chains, but unknotted
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