7L9TA

Crystal structure of dihydrofolate reductase from mycolicibacterium smegmatis in complex with sddc-0001565 inhibitor
Total Genus 41
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The genus trace: a function that shows values of genus (vertical axis) for subchains spanned between the first residue, and all other residues (shown on horizontal axis). The number of the latter residue and the genus of a given subchain are shown interactively.

Total Genus
41
sequence length
156
structure length
156
Chain Sequence
MSMRLIWAQSTSGIIGRDNSIPWRLPEDLARFKEMTMGHPVVMGRLTWESLPASVRPLPGRRNIVVTRDADYRAEGAEVVTDLPDEPDAWVIGGAQIYAMALARADRCEVTEVDIALTPLDGDARAPVLDDSWVATTGEWQTSTSGLRFRFCSYRR
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The genus matrix. At position (x,y) a genus value for a subchain spanned between x’th and y’th residue is shown. Values of the genus are represented by color, according to the scale given on the right.

Structure visualization

After clicking on a point (x,y) in the genus matrix above, a subchain from x to y is shown in color.

Chord Diagram
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publication title Crystal Structure of Acetyl-coenzyme A synthetase synthetase from Coccidioides immitis in complex with PRX
rcsb
molecule tags Oxidoreductase
source organism Mycolicibacterium smegmatis (strain atcc 700084 / mc(2)155)
molecule keywords Dihydrofolate reductase
total genus 41
structure length 156
sequence length 156
ec nomenclature ec 1.5.1.3: Dihydrofolate reductase.
pdb deposition date 2021-01-05

pfam database annotations

chain Pfam Accession Code Pfam Family Identifier Pfam Description
A PF00186 DHFR_1 Dihydrofolate reductase
Image from the rcsb pdb (www.rcsb.org)
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similar chains in the Genus database (?% sequence similarity)
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similar chains in the pdb database (?% sequence similarity)

 
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#similar chains, but unknotted
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