Cryo-em structure of human p97 in complex with npl4/ufd1 and polyubiquitinated ub-eos (fom, class 2)
Total Genus 172
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The genus trace: a function that shows values of genus (vertical axis) for subchains spanned between the first residue, and all other residues (shown on horizontal axis). The number of the latter residue and the genus of a given subchain are shown interactively.

Total Genus
sequence length
structure length
Chain Sequence
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The genus matrix. At position (x,y) a genus value for a subchain spanned between x’th and y’th residue is shown. Values of the genus are represented by color, according to the scale given on the right.

Structure visualization

After clicking on a point (x,y) in the genus matrix above, a subchain from x to y is shown in color.

molecule tags Translocase
molecule keywords Transitional endoplasmic reticulum ATPase
publication title Mechanistic insight into substrate processing and allosteric inhibition of human p97.
pubmed doi rcsb
source organism Homo sapiens
total genus 172
structure length 732
sequence length 753
chains with identical sequence B, C, D, E, F
ec nomenclature ec Vesicle-fusing ATPase.
pdb deposition date 2021-02-06

pfam database annotations

chain Pfam Accession Code Pfam Family Identifier Pfam Description
A PF00004 AAA ATPase family associated with various cellular activities (AAA)
A PF02359 CDC48_N Cell division protein 48 (CDC48), N-terminal domain
A PF02933 CDC48_2 Cell division protein 48 (CDC48), domain 2
A PF09336 Vps4_C Vps4 C terminal oligomerisation domain
A PF17862 AAA_lid_3 AAA+ lid domain
Image from the rcsb pdb (www.rcsb.org)
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similar chains in the Genus database (?% sequence similarity)
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similar chains in the pdb database (?% sequence similarity)

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#similar chains, but unknotted
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#similar chains in the pdb database (?% sequence similarity)
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