7LW8A

Human exonuclease 5 crystal structure in complex with a ssdna
Total Genus 75
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The genus trace: a function that shows values of genus (vertical axis) for subchains spanned between the first residue, and all other residues (shown on horizontal axis). The number of the latter residue and the genus of a given subchain are shown interactively.

Total Genus
75
sequence length
287
structure length
260
Chain Sequence
ILSPMERFHLKYLYVTDLATQNWCELQTAYGKELPGFLVPVTTKEDAWAIKFLNILLLIPTLQSEGHIREFPVFGEVEGVLLVGVIDELHYTAKGELELAELKTRRRPMLPLEAQKKKDCFQVSLYKYIFDAMVQGKVTPASLIHHTKLCLEKPLGPSVLRHAQQGGFSVKSLGDLMELVFLSLTLSDLPVIDILKIEYIHQETATVLGTEIVAFKEKEVRAKVQHYMAYWMGHREPQGVDVEEAWKCRTCTYADICEWR
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The genus matrix. At position (x,y) a genus value for a subchain spanned between x’th and y’th residue is shown. Values of the genus are represented by color, according to the scale given on the right.

Structure visualization

After clicking on a point (x,y) in the genus matrix above, a subchain from x to y is shown in color.

Chord Diagram
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publication title EXO5-DNA structure and BLM interactions direct DNA resection critical for ATR-dependent replication restart.
pubmed doi rcsb
molecule keywords Exonuclease V
molecule tags Hydrolase/dna
source organism Homo sapiens
total genus 75
structure length 260
sequence length 287
ec nomenclature ec 3.1.-.-:
pdb deposition date 2021-02-28

pfam database annotations

chain Pfam Accession Code Pfam Family Identifier Pfam Description
A PF09810 Exo5 Exonuclease V - a 5' deoxyribonuclease
Image from the rcsb pdb (www.rcsb.org)
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similar chains in the Genus database (?% sequence similarity)
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similar chains in the pdb database (?% sequence similarity)

 
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