7MFDA

Autoinhibited braf:(14-3-3)2:mek complex with the braf rbd resolved
Total Genus 62
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The genus trace: a function that shows values of genus (vertical axis) for subchains spanned between the first residue, and all other residues (shown on horizontal axis). The number of the latter residue and the genus of a given subchain are shown interactively.

Total Genus
62
sequence length
583
structure length
408
Chain Sequence
IVRVFLPNKQRTVVPARCGVTVRDSLKKALMMRGLIPECCAVYRIQEKKPIGWDTDISWLTGEELHVEVLHNFVRKTFFTLAFCDFCRKLLFQGFRCQTCGYKFHQRCSRDRSSAPNVHDWEIPDGQITVGQRIGSGSFGTVYKGKWHGDVAVKMLNVTAPTPQQLQAFKNEVGVLRKTRHVNILLFMGYSTKPQLAIVTQWCEGSSLYHHLHIIETKFEMIKLIDIARQTAQGMDYLHAKSIIHRDLKSNNIFLHEDLTVKIGDFGLATVKSRWSGSHQFEQLSGSILWMAPEVIRMQDKNPYSFQSDVYAFGIVLYELMTGQLPYSNINNRDQIIFMVGRGYLSPDLSKVRSNCPKAMKRLMAECLKKKRDERPLFPQILASIELLARSLPKIHRSAEPSLNRAGF
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The genus matrix. At position (x,y) a genus value for a subchain spanned between x’th and y’th residue is shown. Values of the genus are represented by color, according to the scale given on the right.

Structure visualization

After clicking on a point (x,y) in the genus matrix above, a subchain from x to y is shown in color.

Chord Diagram
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publication title Structural insights into the BRAF monomer-to-dimer transition mediated by RAS binding.
pubmed doi rcsb
molecule tags Signaling protein/transferase
source organism Homo sapiens
molecule keywords Serine/threonine-protein kinase B-raf
total genus 62
structure length 408
sequence length 583
ec nomenclature ec 2.7.11.1: non-specific serine/threonine protein kinase.
pdb deposition date 2021-04-09
Image from the rcsb pdb (www.rcsb.org)
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similar chains in the Genus database (?% sequence similarity)
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similar chains in the pdb database (?% sequence similarity)

 
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