7MP6A

Neurofibromin homodimer
Total Genus 660
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The genus trace: a function that shows values of genus (vertical axis) for subchains spanned between the first residue, and all other residues (shown on horizontal axis). The number of the latter residue and the genus of a given subchain are shown interactively.

Total Genus
660
sequence length
2719
structure length
1600
Chain Sequence
RPVEWVQAVVSRFDEQLPIKTHTKVSTEHNKECLINISKYKFSLVISGLTTILKNVNNKNLYLSQLIILDTLEKCLAGQPETMLVKQLLPEICHFLQHAAELRNSASGVLFSLSCNNFNAVFSRISTRLQELTVVDVHDIELLQYINVDCAKLKRLLKETAFKFKALKKVAQLAVINSLEKAFWNWVENYPDEFTKLYQTDMAECAEKLFDLVDGFAESTKRKAAVWPLQIILLILCPEIIQDISKNNMNKKLFLDSLRKALAGHGGSRQLTESAAIACVKLCKASTYISVIFLLVQSMVVDLKNLLFNPSKPFSVDLMIDCLVSCFRISPNQHFKICLASPSTFHYVLVNSLHRIITNLDWWPKIDAVYCHSVELRNMFGETLHKAVQGDLETRSYKYLLLSMVKLIHADPKLLLCNPGSTAELITGLVQLVPQSHMPEIAQEAMEALLVLHQLDSIDLWPVETFWEISSQMLFYICKKLTSSSTEILKWLREILICRNKFLLKNPICRQAQTKLEVALYMFLWNPDTEAVLVAMSCFRHLCEEADIRCGVPNYNTFMEFASVRAALQKRVMALLRRIEHPTAGNTEAWEDTHAKWEQATKLILSLQEWINMTGFLCALGGVCLTPVSKFMDRLLSLMVCNHEKVGLQIRTNVKDLVGLELSPALYPMLFNKLKNTISKFFDSQGQVLLDTNTQFVEQTIAIMKNLLDNHTEGSSEHLGQASIETMMLNLVRYVRVLGNMVHAIQIKTKLCQLVEVMMARRDDLSFCQEMKFRNKMVEYLTDWVMVKCLTRDLDQASMEAVVSLLAGLPLQPEGVELMEAKSQLFLKYFTLFMNLLNDCSGMSRRLASLRHCTVLAMSNLLNANVDSGLMHSIGLGYHKDLQTRATFMEVLTKILQQGVPGTLLNIALLNLGSSDPSLRSAAYNLLCALTCTFNLKIEGQLLETSGLCIPANNTLFIVSISKTLAANEPHLTLEFLEECISGFSKSSIELKHLCLEYMTPWLSNLVRFCKHNDDAKRQRVTAILDKLITMTINEKQMYPSIQAKIWGSLGQLLDVVLDSFIKTSAIKAEVMADTAVALASGNVKLVSSKVIGRMCKIIDKTCLSPTPTLEQHLMWDDIAILARYMLMLSFNNSLDVAAHLPYLFHVVTFLVATGPLSLRASTHGLVINIIHSLCTCSQLHFSEETKQVLRLSLTEFSLPKFYLLFGISKVKSAAVIAFYERETFALTSLETVTEALLEIMEACMRDIPTCKWLDQWTELAQRFAFQYNPSLQPRALVVFGCISKRVSHGQIKQIIRILSKALESCLKYNSQVLIEATVIALTKLQPLLNKDSPLHKALFWVAVAVLQLDEVNLYSAGTALLEQNLHTLDSLRIFNDKSPEEVFMAIRNPLEWHCKQMDHFVGLNFNSNFNFALVGHLLKGYRHPSPAIVARTVRILHTLLTLVNKHRNCDKFEVNTQSVAYLAALLTVSEEVRSDPKIQALLLTVLATLVKYTTDEFDQRILYEYLAEASVVFPKVFPVVHNLLDSKINTLLSLCQDPNLLNPIHGIVQSVVYHEPQYQTSYLQSFGFNGLWRFAGPFIPDYAELIVKFLDALIDTYLP
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The genus matrix. At position (x,y) a genus value for a subchain spanned between x’th and y’th residue is shown. Values of the genus are represented by color, according to the scale given on the right.

Structure visualization

After clicking on a point (x,y) in the genus matrix above, a subchain from x to y is shown in color.

molecule tags Antitumor protein
molecule keywords Isoform I of Neurofibromin
publication title The cryo-EM structure of the human neurofibromin dimer reveals the molecular basis for neurofibromatosis type 1.
pubmed doi rcsb
source organism Homo sapiens
total genus 660
structure length 1600
sequence length 2719
chains with identical sequence B
ec nomenclature
pdb deposition date 2021-05-04
Image from the rcsb pdb (www.rcsb.org)
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similar chains in the Genus database (?% sequence similarity)
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similar chains in the pdb database (?% sequence similarity)

 
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