7R6JA

Co-crystal structure of chaetomium glucosidase with compound 1
Total Genus 265
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The genus trace: a function that shows values of genus (vertical axis) for subchains spanned between the first residue, and all other residues (shown on horizontal axis). The number of the latter residue and the genus of a given subchain are shown interactively.

Total Genus
265
sequence length
778
structure length
765
Chain Sequence
LHSEIGRLNNQSLLWGPYRPNIYFGTRPRIGKSLMTGLMWGKIESYTDFQHTVRYTCEQNEGMKGYGWDEYDPRRGGIQSIHDIQNGLDITTSFVKIPGGAHGGSWAARIKGTLNDDAPKDQKTIVVFYVSQEGENSELEAVPSENEFGYEGDVILKGRSEALGNYKLVVTKGKGVIPQSDHDLSRLRGPGQTVVQSLTYPDEVLWQAKPILFQQLKAGIDWLVENKYDVADPPPPWQVYLLANKPGSGNVHIVQKVFEGDFEFDILFSSESAGKEVTSKDLEREVKQATEVFGERFARVFDLKAPFQGDNYKKFGKSMFSNLIGGIGYFYGHSLVDRSYAPEYDEENEGFWEDAAEARARHQEALEGPYELFTSIPSRPFFPRGFLWDEGFHLLPIADWDIDLALEIIKSWYNLMDEDGWIAREQILGAEARSKVPKEFQTQYPHYANPPTLFLVLDNFVERLRKLDETLSTASVDNPEVGLEYLRRLYPLLRRQFDWFRKTQAGDIKSYDREAYSTKEAYRWRGRTVSHCLTSGLDDYPRPQPPHPGELHVDLMSWVGVMVKSLISIGSLLGATEDVEFYTKVLDAIEHNLDDLHWSEKEGCYCDATIDEFEEHKLVCHKGYISLFPFLTGLLKPDSPKLGKLLALIGDESELWSPYGLRSLSKKDEFYGTAENYWRSPVWININYLAIVQLYNIATQDGPYKETARDLYTRLRKNIVETVYRNWEETGFAWEQYNPETGKGQRTQHFTGWTSLVVKIMSGHH
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The genus matrix. At position (x,y) a genus value for a subchain spanned between x’th and y’th residue is shown. Values of the genus are represented by color, according to the scale given on the right.

Structure visualization

After clicking on a point (x,y) in the genus matrix above, a subchain from x to y is shown in color.

molecule tags Hydrolase/inhibitor
molecule keywords Chaetomium alpha glucosidase
publication title Structure-Based Design of Potent Iminosugar Inhibitors of Endoplasmic Reticulum alpha-Glucosidase I with Anti-SARS-CoV-2 Activity.
pubmed doi rcsb
source organism Chaetomium thermophilum (strain dsm 1495 / cbs 144.50 / imi 039719)
total genus 265
structure length 765
sequence length 778
chains with identical sequence B
ec nomenclature ec 3.2.1.106: mannosyl-oligosaccharide glucosidase.
pdb deposition date 2021-06-22
Image from the rcsb pdb (www.rcsb.org)
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similar chains in the Genus database (?% sequence similarity)
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similar chains in the pdb database (?% sequence similarity)

 
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#similar chains, but unknotted
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