7RT4A

Kras g12d in complex with compound 5b (7-(8-chloronaphthalen-1-yl)-8-fluoro-2-{[(2s)-1-methylpyrrolidin-2-yl]methoxy}-4-(piperazin-1-yl)pyrido[4,3-d]pyrimidine)
Total Genus 65
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The genus trace: a function that shows values of genus (vertical axis) for subchains spanned between the first residue, and all other residues (shown on horizontal axis). The number of the latter residue and the genus of a given subchain are shown interactively.

Total Genus
65
sequence length
170
structure length
170
Chain Sequence
GMTEYKLVVVGADGVGKSALTIQLIQNHFVDEYDPTIEDSYRKQVVIDGETSLLDILDTAGQEEYSAMRDQYMRTGEGFLLVFAINNTKSFEDIHHYREQIKRVKDSEDVPMVLVGNKSDLPSRTVDTKQAQDLARSYGIPFIETSAKTRQGVDDAFYTLVREIRKHKEK
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The genus matrix. At position (x,y) a genus value for a subchain spanned between x’th and y’th residue is shown. Values of the genus are represented by color, according to the scale given on the right.

Structure visualization

After clicking on a point (x,y) in the genus matrix above, a subchain from x to y is shown in color.

Chord Diagram
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molecule tags Hydrolase/inhibitor
molecule keywords Isoform 2B of GTPase KRas
publication title Identification of MRTX1133, a Noncovalent, Potent, and Selective KRAS G12D Inhibitor.
pubmed doi rcsb
source organism Homo sapiens
total genus 65
structure length 170
sequence length 170
ec nomenclature ec 3.6.5.2: small monomeric GTPase.
pdb deposition date 2021-08-12
Image from the rcsb pdb (www.rcsb.org)
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similar chains in the Genus database (?% sequence similarity)
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similar chains in the pdb database (?% sequence similarity)

 
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