7TO5A

Hiv-1 wild type protease with grl-05816a, with c-4 substituted cyclohexane-fused bis-tetrahydrofuran (chf-thf) derivatives as p2-ligand [diastereomer 1]
Total Genus 18
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The genus trace: a function that shows values of genus (vertical axis) for subchains spanned between the first residue, and all other residues (shown on horizontal axis). The number of the latter residue and the genus of a given subchain are shown interactively.

Total Genus
18
sequence length
99
structure length
99
Chain Sequence
PQITLWKRPLVTIKIGGQLKEALLDTGADDTVIEEMSLPGRWKPKMIGGIGGFIKVRQYDQIIIEIAGHKAIGTVLVGPTPVNIIGRNLLTQIGATLNF
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The genus matrix. At position (x,y) a genus value for a subchain spanned between x’th and y’th residue is shown. Values of the genus are represented by color, according to the scale given on the right.

Structure visualization

After clicking on a point (x,y) in the genus matrix above, a subchain from x to y is shown in color.

Chord Diagram
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publication title Design, Synthesis and X-Ray Structural Studies of Potent HIV-1 Protease Inhibitors Containing C-4 Substituted Tricyclic Hexahydro-Furofuran Derivatives as P2 Ligands.
pubmed doi rcsb
molecule tags Antiviral protein/inhibitor
source organism Human immunodeficiency virus 1
molecule keywords Protease
total genus 18
structure length 99
sequence length 99
chains with identical sequence B
ec nomenclature ec 2.7.7.-:
pdb deposition date 2022-01-23
Image from the rcsb pdb (www.rcsb.org)
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similar chains in the Genus database (?% sequence similarity)
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