7UJ7A

Estrogen receptor alpha ligand binding domain y537s mutant in complex with ru39411
Total Genus 81
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The genus trace: a function that shows values of genus (vertical axis) for subchains spanned between the first residue, and all other residues (shown on horizontal axis). The number of the latter residue and the genus of a given subchain are shown interactively.

Total Genus
81
sequence length
241
structure length
216
Chain Sequence
ALSLTADQMVSALLDAEPPILYSEEASMMGLLTNLADRELVHMINWAKRVPGFVDLTLHDQVHLLESAWLEILMIGLVWRSMEHPGKLLFAPNLLLDRNQGEGMVEIFDMLLATSSRFRMMNLQGEEFVCLKSIILLNSGVYTFLKSLEEKDHIHRVLDKITDTLIHLMAKAGLTLQQQHQRLAQLLLILSHIRHMSNKGMEHLLSDLLLEMLDAH
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The genus matrix. At position (x,y) a genus value for a subchain spanned between x’th and y’th residue is shown. Values of the genus are represented by color, according to the scale given on the right.

Structure visualization

After clicking on a point (x,y) in the genus matrix above, a subchain from x to y is shown in color.

publication title Stereospecific lasofoxifene derivatives reveal the interplay between estrogen receptor alpha stability and antagonistic activity in ESR1 mutant breast cancer cells.
pubmed doi rcsb
molecule tags Transcription
source organism Homo sapiens
molecule keywords Estrogen receptor
total genus 81
structure length 216
sequence length 241
chains with identical sequence B, C, D
ec nomenclature
pdb deposition date 2022-03-30
Image from the rcsb pdb (www.rcsb.org)
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similar chains in the Genus database (?% sequence similarity)
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similar chains in the pdb database (?% sequence similarity)

 
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