7YFKA

The structure of human pregnane x receptor in complex with an src-1 coactivator peptide and a limonoid compound, nomilin
Total Genus 111
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The genus trace: a function that shows values of genus (vertical axis) for subchains spanned between the first residue, and all other residues (shown on horizontal axis). The number of the latter residue and the genus of a given subchain are shown interactively.

Total Genus
111
sequence length
319
structure length
287
Chain Sequence
GLTEEQRMMIRELMDAQMKTFDTTFSHFKNFRLPGVSREEAAKWSQVRKDLCSLKVSLQLRGEDGSVWNYKPPADSGGKEIFSLLPHMADMSTYMFKGIISFAKVISYFRDLPIEDQISLLKGAAFELCQLRFNTVFNAETGTWECGRLSYCLEDQQLLLEPMLKFHYMLKKLQLHEEEYVLMQAISLFSPDRPGVLQHRVVDQLQEQFAITLKSYIECNRPQPAHRFLFLKIMAMLTELRSINAQHTQRLLRIQDIHPFATPLMQELFGITSSLTERHKILHRLLQ
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The genus matrix. At position (x,y) a genus value for a subchain spanned between x’th and y’th residue is shown. Values of the genus are represented by color, according to the scale given on the right.

Structure visualization

After clicking on a point (x,y) in the genus matrix above, a subchain from x to y is shown in color.

Chord Diagram
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publication title Pregnane X receptor agonist nomilin extends lifespan and healthspan in preclinical models through detoxification functions.
pubmed doi rcsb
molecule tags Transcription
source organism Homo sapiens
molecule keywords Nuclear receptor subfamily 1 group I member 2,Nuclear receptor coactivator 1
total genus 111
structure length 287
sequence length 319
chains with identical sequence B
ec nomenclature ec 2.3.1.48: histone acetyltransferase.
pdb deposition date 2022-07-08
Image from the rcsb pdb (www.rcsb.org)
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