8B7HA

Crystal structure of human gremlin-1 in complex with fab
Total Genus 4
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The genus trace: a function that shows values of genus (vertical axis) for subchains spanned between the first residue, and all other residues (shown on horizontal axis). The number of the latter residue and the genus of a given subchain are shown interactively.

Total Genus
4
sequence length
93
structure length
74
Chain Sequence
DWCKTQPLKQTRTIINRFCYGQCNSFYIPRHIEGSFQSCSFCKPKKFTTMMVTLNCKKRVTRVKQCRCISIDLD
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The genus matrix. At position (x,y) a genus value for a subchain spanned between x’th and y’th residue is shown. Values of the genus are represented by color, according to the scale given on the right.

Structure visualization

After clicking on a point (x,y) in the genus matrix above, a subchain from x to y is shown in color.

publication title Discovery of ginisortamab, a potent and novel anti-gremlin-1 antibody in clinical development for the treatment of cancer.
pubmed doi rcsb
molecule tags Signaling protein
source organism Homo sapiens
molecule keywords Fab antibody fragment (light chain)
total genus 4
structure length 74
sequence length 93
ec nomenclature
pdb deposition date 2022-09-30
Image from the rcsb pdb (www.rcsb.org)
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similar chains in the Genus database (?% sequence similarity)
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similar chains in the pdb database (?% sequence similarity)

 
#similar chains in the Genus database (?% sequence similarity)
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#similar chains, but unknotted
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#similar chains in the pdb database (?% sequence similarity)
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