8CX5A

Crystal structure of small molecule alpha,beta-ketoamide 4 covalently bound to k-ras(g12r)
Total Genus 66
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The genus trace: a function that shows values of genus (vertical axis) for subchains spanned between the first residue, and all other residues (shown on horizontal axis). The number of the latter residue and the genus of a given subchain are shown interactively.

Total Genus
66
sequence length
170
structure length
170
Chain Sequence
GMTEYKLVVVGARGVGKSALTIQLIQNHFVDEYDPTIEDSYRKQVVIDGETSLLDILDTAGQEEYSAMRDQYMRTGEGFLLVFAINNTKSFEDIHHYREQIKRVKDSEDVPMVLVGNKSDLPSRTVDTKQAQDLARSYGIPFIETSAKTRQGVDDAFYTLVREIRKHKEK
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The genus matrix. At position (x,y) a genus value for a subchain spanned between x’th and y’th residue is shown. Values of the genus are represented by color, according to the scale given on the right.

Structure visualization

After clicking on a point (x,y) in the genus matrix above, a subchain from x to y is shown in color.

Chord Diagram
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publication title Chemoselective Covalent Modification of K-Ras(G12R) with a Small Molecule Electrophile.
pubmed doi rcsb
molecule tags Signaling protein/inhibitor
source organism Homo sapiens
molecule keywords Isoform 2B of GTPase KRas
total genus 66
structure length 170
sequence length 170
chains with identical sequence B
ec nomenclature ec 3.6.5.2: small monomeric GTPase.
pdb deposition date 2022-05-19
Image from the rcsb pdb (www.rcsb.org)
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similar chains in the Genus database (?% sequence similarity)
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similar chains in the pdb database (?% sequence similarity)

 
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