8DCHA

Crystal structure of a highly resistant hiv-1 protease clinical isolate pr10x with grl-0519 (tris-tetrahydrofuran as p2 ligand)
Total Genus 22
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The genus trace: a function that shows values of genus (vertical axis) for subchains spanned between the first residue, and all other residues (shown on horizontal axis). The number of the latter residue and the genus of a given subchain are shown interactively.

Total Genus
22
sequence length
99
structure length
99
Chain Sequence
PQITLWKRPFVTVKIGGQITEALLDTGADDTIIENISLPGRWKPKIIQGIGGFLKVRQYDQIPIEIEGHKVIGSVVVGPTPVNVIGRNVMSQLGATLNF
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The genus matrix. At position (x,y) a genus value for a subchain spanned between x’th and y’th residue is shown. Values of the genus are represented by color, according to the scale given on the right.

Structure visualization

After clicking on a point (x,y) in the genus matrix above, a subchain from x to y is shown in color.

Chord Diagram
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publication title HIV-1 protease with 10 lopinavir and darunavir resistance mutations exhibits altered inhibition, structural rearrangements and extreme dynamics.
pubmed doi rcsb
molecule tags Viral protein, hydrolase/inhibitor
source organism Human immunodeficiency virus 1
molecule keywords Protease
total genus 22
structure length 99
sequence length 99
chains with identical sequence B
ec nomenclature ec 2.7.7.49: RNA-directed DNA polymerase.
pdb deposition date 2022-06-16
Image from the rcsb pdb (www.rcsb.org)
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similar chains in the Genus database (?% sequence similarity)
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similar chains in the pdb database (?% sequence similarity)

 
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#similar chains, but unknotted
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