8FCBE

Cryo-em structure of the human trpv4 - rhoa in complex with gsk1016790a
Total Genus 42
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The genus trace: a function that shows values of genus (vertical axis) for subchains spanned between the first residue, and all other residues (shown on horizontal axis). The number of the latter residue and the genus of a given subchain are shown interactively.

Total Genus
42
sequence length
190
structure length
190
Chain Sequence
MAAIRKKLVIVGDGACGKTCLLIVFSKDQFPEVYVPTVFENYVADIEVDGKQVELALWDTAGQEDYDRLRPLSYPDTDVILMCFSIDSPDSLENIPEKWTPEVKHFCPNVPIILVGNKKDLRNDEHTRRELAKMKQEPVKPEEGRDMANRIGAFGYMECSAKTKDGVREVFEMATRAALQARRGKKKSGC
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The genus matrix. At position (x,y) a genus value for a subchain spanned between x’th and y’th residue is shown. Values of the genus are represented by color, according to the scale given on the right.

Structure visualization

After clicking on a point (x,y) in the genus matrix above, a subchain from x to y is shown in color.

Chord Diagram
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publication title TRPV4-Rho GTPase complex structures reveal mechanisms of gating and disease.
pubmed doi rcsb
molecule tags Membrane protein
source organism Homo sapiens
molecule keywords Transient receptor potential cation channel subfamily V member 4
total genus 42
structure length 190
sequence length 190
chains with identical sequence F, G, H
ec nomenclature ec 3.6.5.2: small monomeric GTPase.
pdb deposition date 2022-12-01
Image from the rcsb pdb (www.rcsb.org)
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similar chains in the Genus database (?% sequence similarity)
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similar chains in the pdb database (?% sequence similarity)

 
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#similar chains, but unknotted
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