8FP0A

Ternary complex of cdk2 with small molecule ligands tw8672 and roscovitine
Total Genus 76
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The genus trace: a function that shows values of genus (vertical axis) for subchains spanned between the first residue, and all other residues (shown on horizontal axis). The number of the latter residue and the genus of a given subchain are shown interactively.

Total Genus
76
sequence length
297
structure length
274
Chain Sequence
ENFQKVEKIGEGTYGVVYKARNKLTGEVVALKKIRTAIREISLLKELNHPNIVKLLDVIHTKLYLVFEFLHQDLKKFMDASALTGIPLPLIKSYLFQLLQGLAFCHSHRVLHRDLKPQNLLINTEGAIKLADFGLARAVVTLWYRAPEILLGCKYYSTAVDIWSLGCIFAEMVTRRALFPGDSEIDQLFRIFRTLGTPDEVVWPGVTSMPDYKPSFPKWARQDFSKVVPPLDEDGRSLLSQMLHYDPNKRISAKAALAHPFFQDVTKPVPHLRL
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The genus matrix. At position (x,y) a genus value for a subchain spanned between x’th and y’th residue is shown. Values of the genus are represented by color, according to the scale given on the right.

Structure visualization

After clicking on a point (x,y) in the genus matrix above, a subchain from x to y is shown in color.

Chord Diagram
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publication title Development of allosteric and selective CDK2 inhibitors for contraception with negative cooperativity to cyclin binding.
pubmed doi rcsb
molecule tags Cell cycle, transferase
source organism Homo sapiens
molecule keywords Cyclin-dependent kinase 2
total genus 76
structure length 274
sequence length 297
ec nomenclature ec 2.7.11.22: cyclin-dependent kinase.
pdb deposition date 2023-01-03
Image from the rcsb pdb (www.rcsb.org)
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