8PRKA

The r78k and d117e active site variants of saccharomyces cerevisiae soluble inorganic pyrophosphatase: structural studies and mechanistic implications
Total Genus 84
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The genus trace: a function that shows values of genus (vertical axis) for subchains spanned between the first residue, and all other residues (shown on horizontal axis). The number of the latter residue and the genus of a given subchain are shown interactively.

Total Genus
84
sequence length
282
structure length
282
Chain Sequence
TYTTRQIGAKNTLEYKVYIEKDGKPVSAFHDIPLYADKENNIFNMVVEIPRWTNAKLEITKEETLNPIIQDTKKGKLKFVRNCFPHHGYIHNYGAFPQTWEDPNVSHPETKAVGDNDPIDVLEIGETIAYTGQVKQVKALGIMALLDEGETDWKVIAIDINDPLAPKLNDIEDVEKYFPGLLRATNEWFRIYKIPDGKPENQFAFSGEAKNKKYALDIIKETHDSWKQLIAGKSSDSKGIDLTNVTLPDTPTYSKAASDAIPPASLKADAPIDKSIDKWFFI
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The genus matrix. At position (x,y) a genus value for a subchain spanned between x’th and y’th residue is shown. Values of the genus are represented by color, according to the scale given on the right.

Structure visualization

After clicking on a point (x,y) in the genus matrix above, a subchain from x to y is shown in color.

Chord Diagram
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publication title The R78K and D117E active-site variants of Saccharomyces cerevisiae soluble inorganic pyrophosphatase: structural studies and mechanistic implications.
pubmed doi rcsb
molecule tags Hydrolase
source organism Saccharomyces cerevisiae
molecule keywords PROTEIN (INORGANIC PYROPHOSPHATASE)
total genus 84
structure length 282
sequence length 282
chains with identical sequence B
ec nomenclature ec 3.6.1.1: Inorganic diphosphatase.
pdb deposition date 1998-09-16

pfam database annotations

chain Pfam Accession Code Pfam Family Identifier Pfam Description
A PF00719 Pyrophosphatase Inorganic pyrophosphatase
Image from the rcsb pdb (www.rcsb.org)
cath code
ClassArchitectureTopologyHomologyDomain
3.90.80.10 Alpha Beta Alpha-Beta Complex Inorganic Pyrophosphatase Inorganic pyrophosphatase 8prkA00
3EIZA 2AUUA 5H4FA 1FAJA 4ECPA 4Z70A 1I6TA 4Z71A 3GVFA 3SW5A 1WCFA 2AU9A 5KDFA 2AU8A 3D53A 1OBWA 3Q3LA 2IK7A 8PRKA 1MJZA 2IK1A 1MJYA 1MJWA 3I4QA 2BQYA 2UXSA 2EIPA 5TEAA 1E6AA 2IK4A 2IK6A 1QEZA 3LO0A 3I98A 3R5VA 3FQ3A 3Q46A 2AU6A 1HUJA 3Q4WA 2PRDA 2AU7A 1IPWA 1IGPA 1WGIA 1I40A 1YPPA 4QLZA 3EJ2A 4Z72A 1HUKA 1E9GA 3R6EA 4LUGA 3TR4A 4XELA 2IHPA 1MJXA 1JFDA 117EA 4Z74A 3D63A 2IK0A 4QMBA 1M38A 1SXVA 1TWLA 1YGZA 2IK9A 3EMJA 4UM4A 2BQXA 3Q5VA 2IK2A 1WGJA 3EJ0A 3LD3A 1UDEA 3R5UA 1PYPA 1INOA 4Z73A 3EIYA 5KDEA
chains in the Genus database with same CATH superfamily
3EIZA 2AUUA 5H4FA 1FAJA 4ECPA 4Z70A 1I6TA 4Z71A 3GVFA 3SW5A 1WCFA 2AU9A 5KDFA 2AU8A 3D53A 1OBWA 3Q3LA 2IK7A 8PRKA 1MJZA 2IK1A 1MJYA 1MJWA 3I4QA 2BQYA 2UXSA 2EIPA 5TEAA 1E6AA 2IK4A 2IK6A 1QEZA 3LO0A 3I98A 3R5VA 3FQ3A 3Q46A 2AU6A 1HUJA 3Q4WA 2PRDA 2AU7A 1IPWA 1IGPA 1WGIA 1I40A 1YPPA 4QLZA 3EJ2A 4Z72A 1HUKA 1E9GA 3R6EA 4LUGA 3TR4A 4XELA 2IHPA 1MJXA 1JFDA 117EA 4Z74A 3D63A 2IK0A 4QMBA 1M38A 1SXVA 1TWLA 1YGZA 2IK9A 3EMJA 4UM4A 2BQXA 3Q5VA 2IK2A 1WGJA 3EJ0A 3LD3A 1UDEA 3R5UA 1PYPA 1INOA 4Z73A 3EIYA 5KDEA
chains in the Genus database with same CATH topology
3EIZA 2AUUA 5H4FA 1FAJA 4ECPA 4Z70A 1I6TA 4Z71A 3GVFA 3SW5A 1WCFA 2AU9A 5KDFA 2AU8A 3D53A 1OBWA 3Q3LA 2IK7A 8PRKA 1MJZA 2IK1A 1MJYA 1MJWA 3I4QA 2BQYA 2UXSA 2EIPA 5TEAA 1E6AA 2IK4A 2IK6A 1QEZA 3LO0A 3I98A 3R5VA 3FQ3A 3Q46A 2AU6A 1HUJA 3Q4WA 2PRDA 2AU7A 1IPWA 1IGPA 1WGIA 1I40A 1YPPA 4QLZA 3EJ2A 4Z72A 1HUKA 1E9GA 3R6EA 4LUGA 3TR4A 4XELA 2IHPA 1MJXA 1JFDA 117EA 4Z74A 3D63A 2IK0A 4QMBA 1M38A 1SXVA 1TWLA 1YGZA 2IK9A 3EMJA 4UM4A 2BQXA 3Q5VA 2IK2A 1WGJA 3EJ0A 3LD3A 1UDEA 3R5UA 1PYPA 1INOA 4Z73A 3EIYA 5KDEA
chains in the Genus database with same CATH homology


 
#chains in the Genus database with same CATH superfamily
 3EIZ A;  2AUU A;  5H4F A;  1FAJ A;  4ECP A;  4Z70 A;  1I6T A;  4Z71 A;  3GVF A;  3SW5 A;  1WCF A;  2AU9 A;  5KDF A;  2AU8 A;  3D53 A;  1OBW A;  3Q3L A;  2IK7 A;  8PRK A;  1MJZ A;  2IK1 A;  1MJY A;  1MJW A;  3I4Q A;  2BQY A;  2UXS A;  2EIP A;  5TEA A;  1E6A A;  2IK4 A;  2IK6 A;  1QEZ A;  3LO0 A;  3I98 A;  3R5V A;  3FQ3 A;  3Q46 A;  2AU6 A;  1HUJ A;  3Q4W A;  2PRD A;  2AU7 A;  1IPW A;  1IGP A;  1WGI A;  1I40 A;  1YPP A;  4QLZ A;  3EJ2 A;  4Z72 A;  1HUK A;  1E9G A;  3R6E A;  4LUG A;  3TR4 A;  4XEL A;  2IHP A;  1MJX A;  1JFD A;  117E A;  4Z74 A;  3D63 A;  2IK0 A;  4QMB A;  1M38 A;  1SXV A;  1TWL A;  1YGZ A;  2IK9 A;  3EMJ A;  4UM4 A;  2BQX A;  3Q5V A;  2IK2 A;  1WGJ A;  3EJ0 A;  3LD3 A;  1UDE A;  3R5U A;  1PYP A;  1INO A;  4Z73 A;  3EIY A;  5KDE A; 
#chains in the Genus database with same CATH topology
 3EIZ A;  2AUU A;  5H4F A;  1FAJ A;  4ECP A;  4Z70 A;  1I6T A;  4Z71 A;  3GVF A;  3SW5 A;  1WCF A;  2AU9 A;  5KDF A;  2AU8 A;  3D53 A;  1OBW A;  3Q3L A;  2IK7 A;  8PRK A;  1MJZ A;  2IK1 A;  1MJY A;  1MJW A;  3I4Q A;  2BQY A;  2UXS A;  2EIP A;  5TEA A;  1E6A A;  2IK4 A;  2IK6 A;  1QEZ A;  3LO0 A;  3I98 A;  3R5V A;  3FQ3 A;  3Q46 A;  2AU6 A;  1HUJ A;  3Q4W A;  2PRD A;  2AU7 A;  1IPW A;  1IGP A;  1WGI A;  1I40 A;  1YPP A;  4QLZ A;  3EJ2 A;  4Z72 A;  1HUK A;  1E9G A;  3R6E A;  4LUG A;  3TR4 A;  4XEL A;  2IHP A;  1MJX A;  1JFD A;  117E A;  4Z74 A;  3D63 A;  2IK0 A;  4QMB A;  1M38 A;  1SXV A;  1TWL A;  1YGZ A;  2IK9 A;  3EMJ A;  4UM4 A;  2BQX A;  3Q5V A;  2IK2 A;  1WGJ A;  3EJ0 A;  3LD3 A;  1UDE A;  3R5U A;  1PYP A;  1INO A;  4Z73 A;  3EIY A;  5KDE A; 
#chains in the Genus database with same CATH homology
 3EIZ A;  2AUU A;  5H4F A;  1FAJ A;  4ECP A;  4Z70 A;  1I6T A;  4Z71 A;  3GVF A;  3SW5 A;  1WCF A;  2AU9 A;  5KDF A;  2AU8 A;  3D53 A;  1OBW A;  3Q3L A;  2IK7 A;  8PRK A;  1MJZ A;  2IK1 A;  1MJY A;  1MJW A;  3I4Q A;  2BQY A;  2UXS A;  2EIP A;  5TEA A;  1E6A A;  2IK4 A;  2IK6 A;  1QEZ A;  3LO0 A;  3I98 A;  3R5V A;  3FQ3 A;  3Q46 A;  2AU6 A;  1HUJ A;  3Q4W A;  2PRD A;  2AU7 A;  1IPW A;  1IGP A;  1WGI A;  1I40 A;  1YPP A;  4QLZ A;  3EJ2 A;  4Z72 A;  1HUK A;  1E9G A;  3R6E A;  4LUG A;  3TR4 A;  4XEL A;  2IHP A;  1MJX A;  1JFD A;  117E A;  4Z74 A;  3D63 A;  2IK0 A;  4QMB A;  1M38 A;  1SXV A;  1TWL A;  1YGZ A;  2IK9 A;  3EMJ A;  4UM4 A;  2BQX A;  3Q5V A;  2IK2 A;  1WGJ A;  3EJ0 A;  3LD3 A;  1UDE A;  3R5U A;  1PYP A;  1INO A;  4Z73 A;  3EIY A;  5KDE A; 
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