8PXUA

Targeting extended blood antigens by akkermansia muciniphila enzymes unveils a missing link for generating universal donor blood
Total Genus 233
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The genus trace: a function that shows values of genus (vertical axis) for subchains spanned between the first residue, and all other residues (shown on horizontal axis). The number of the latter residue and the genus of a given subchain are shown interactively.

Total Genus
233
sequence length
646
structure length
646
Chain Sequence
QEQIIPKPAEITLFTGSPARLTPDSLIITETQDKAFLDQAGQLQQMLSAGTGLPLPLKPAGQASKKAACIVIKKDPALAARGEEAYSIQSSPSGIILSAADARGIFYAGQSLVQMMPSVFHDRTGDKSAVRWNISETPFRITDYPRFSWRALMIDEARHFFGEKTIKQIIDQMALLKMNILHWHLTDDTGWRIEIKKYPRLTSIGSKRRESEIGTWNSGKSDGTPHEGFYTQEQIRDIVQYAARRNITIVPEIEMPGHASAAAVAYPFLSLKTPGEVPTTFIVNTAFDPTSEKTYAFLSDVLDEVTAIFPGRIIHIGGDEVRYDKQWKGVPEIEEFMKKNGMKSYADVQMHFTNRMSGIIAQKGRRMMGWNEIYGHDVNGDGGGKAGAKLDTNAVIQFWKGNTSLAKNAIRDGHDVINSLHTSTYLDYSYGSIPLQKAYGFEPVFPGLEKQYHSRVKGLGAQVWTEWISTPERLHYQAFPRACAFAEVGWTPAGKKDFPDFKKRLKAYSERMDLMGIKFARNVISQIDKSDFFNTPRIGTWTPATLTREEHSFDVTKLVKASGKHTVTLLYDKGAHAIEIESVALYENSREVSRDAHAGRSGAHKENIQYILNAPAPRQGATYTVKANFKGAGGRDSHGTVYFETP
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The genus matrix. At position (x,y) a genus value for a subchain spanned between x’th and y’th residue is shown. Values of the genus are represented by color, according to the scale given on the right.

Structure visualization

After clicking on a point (x,y) in the genus matrix above, a subchain from x to y is shown in color.

molecule tags Hydrolase
molecule keywords Beta-N-acetylhexosaminidase
publication title Akkermansia muciniphila exoglycosidases target extended blood group antigens to generate ABO-universal blood
rcsb
source organism Akkermansia muciniphila
total genus 233
structure length 646
sequence length 646
chains with identical sequence B, C
ec nomenclature ec 3.2.1.52: beta-N-acetylhexosaminidase.
pdb deposition date 2023-07-24
Image from the rcsb pdb (www.rcsb.org)
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