8R4QB

Salt inducible kinase 3 in complex with inhibitor
Total Genus 55
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The genus trace: a function that shows values of genus (vertical axis) for subchains spanned between the first residue, and all other residues (shown on horizontal axis). The number of the latter residue and the genus of a given subchain are shown interactively.

Total Genus
55
sequence length
264
structure length
246
Chain Sequence
EVQLVQSGAGVKKPGSSVKVSCKSSGGTSGSSAVSWIRQAPGQGVEWMGGITSIFGPANYAQKFQDRLKITADKATNTVYMELSGLTFEDTAVYYCARVGDYNFWNGHYRSGYYFDLWGRGTLVTVSSVLTQPPSASGTPGQRVTISCSGSSSNIGSNTVNWYQQLPGTAPKLLIYSNTQRPSGVPDRFSGSKSATSASLAISGLQSEDEADYYCAAWDDSLNGHVVFGGGTKVTVLGAAAENLYF
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The genus matrix. At position (x,y) a genus value for a subchain spanned between x’th and y’th residue is shown. Values of the genus are represented by color, according to the scale given on the right.

Structure visualization

After clicking on a point (x,y) in the genus matrix above, a subchain from x to y is shown in color.

publication title The structures of salt inducible kinase 3 in complex with pharmacological inhibitors reveal determinants for binding and selectivity
doi rcsb
molecule tags Ligase
source organism Homo sapiens
molecule keywords Serine/threonine-protein kinase SIK3
total genus 55
structure length 246
sequence length 264
chains with identical sequence D, F, H, J, L
ec nomenclature
pdb deposition date 2023-11-14
Image from the rcsb pdb (www.rcsb.org)
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similar chains in the pdb database (?% sequence similarity)

 
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