8R8DE

Cryo-em structure of coagulation factor beta-xiia in complex with the garadacimab fab fragment (symmetric dimer)
Total Genus 25
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The genus trace: a function that shows values of genus (vertical axis) for subchains spanned between the first residue, and all other residues (shown on horizontal axis). The number of the latter residue and the genus of a given subchain are shown interactively.

Total Genus
25
sequence length
128
structure length
128
Chain Sequence
VQLLESGGGLVQPGGSLRLSCAASGFTFSKYIMQWVRQAPGKGLEWVSGIDIPTKGTVYADSVKGRFTISRDNSKNTLYLQMNSLRAEDTAVYYCARALPRSGYLISPHYYYYALDVWGQGTTVTVSS
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The genus matrix. At position (x,y) a genus value for a subchain spanned between x’th and y’th residue is shown. Values of the genus are represented by color, according to the scale given on the right.

Structure visualization

After clicking on a point (x,y) in the genus matrix above, a subchain from x to y is shown in color.

Chord Diagram
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molecule tags Blood clotting
molecule keywords Coagulation factor XII
publication title Structural basis for inhibition of beta-FXIIa by garadacimab
rcsb
source organism Homo sapiens
total genus 25
structure length 128
sequence length 128
chains with identical sequence H
ec nomenclature
pdb deposition date 2023-11-29
Image from the rcsb pdb (www.rcsb.org)
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similar chains in the Genus database (?% sequence similarity)
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similar chains in the pdb database (?% sequence similarity)

 
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#similar chains, but unknotted
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