8RDTA

Cereblon isoform 4 from magnetospirillum gryphiswaldense in complex with spiro-isoxazol based compound 8j
Total Genus 22
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The genus trace: a function that shows values of genus (vertical axis) for subchains spanned between the first residue, and all other residues (shown on horizontal axis). The number of the latter residue and the genus of a given subchain are shown interactively.

Total Genus
22
sequence length
102
structure length
102
Chain Sequence
SIFRCRQCGQTISRRDWLLPMGGDHEHVVFNPAGMIFRVWCFSLAQGLRLIGAPSGEFSWFKGYDWTIALCGQCGSHLGWHYEGGSQPQTFFGLIKDRLAEG
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The genus matrix. At position (x,y) a genus value for a subchain spanned between x’th and y’th residue is shown. Values of the genus are represented by color, according to the scale given on the right.

Structure visualization

After clicking on a point (x,y) in the genus matrix above, a subchain from x to y is shown in color.

publication title Discovery and characterization of potent spiro-isoxazole-based cereblon ligands with a novel binding mode.
pubmed doi rcsb
molecule keywords Cereblon isoform 4
molecule tags Signaling protein
source organism Magnetospirillum gryphiswaldense
total genus 22
structure length 102
sequence length 102
chains with identical sequence B, C
ec nomenclature
pdb deposition date 2023-12-08
Image from the rcsb pdb (www.rcsb.org)
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similar chains in the Genus database (?% sequence similarity)
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similar chains in the pdb database (?% sequence similarity)

 
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#similar chains, but unknotted
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