8ROYA

Structure of the human ddb1-dda1-dcaf15 e3 ubiquitin ligase bound to compound furan 24
Total Genus 41
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The genus trace: a function that shows values of genus (vertical axis) for subchains spanned between the first residue, and all other residues (shown on horizontal axis). The number of the latter residue and the genus of a given subchain are shown interactively.

Total Genus
41
sequence length
567
structure length
331
Chain Sequence
EHVLKQLERVKISGQLSPRLFRKLPPRVCVSLKNIVDEGHIFLGFSKCGRYVLSYTSSFYIYHLYWWEFNVHSKLKLVRQVRLFQDEEIYSDLYLTVCEWPSDASKVIVFGFNNHRDIYVSTVAVPPPGCLRHGFMLHTKYQVVYPFPTFQPAFQLKKDQVVLLNTSYSLVACAVSVHSFCQILYVVTDLRGRNLRPMRQYLTVEQLTLDFEYVINEVIRHDATWGHQFCSFSDYDIVILEVCPETNQVLINIGLLLLPKTYHTSLKVAWDLNTGIFETVSVGDLTEVVWSSYRKSCVDMVMKWLVPESSGRYVNRMTNLADSERYTWIVL
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The genus matrix. At position (x,y) a genus value for a subchain spanned between x’th and y’th residue is shown. Values of the genus are represented by color, according to the scale given on the right.

Structure visualization

After clicking on a point (x,y) in the genus matrix above, a subchain from x to y is shown in color.

publication title Optimization of Potent Ligands for the E3 Ligase DCAF15 and Evaluation of Their Use in Heterobifunctional Degraders.
pubmed doi rcsb
molecule tags Ligase
source organism Homo sapiens
molecule keywords DDB1- and CUL4-associated factor 15
total genus 41
structure length 331
sequence length 567
ec nomenclature
pdb deposition date 2024-01-12
Image from the rcsb pdb (www.rcsb.org)
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similar chains in the pdb database (?% sequence similarity)

 
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