8SR7A

Cryo-em structure of trpm2 chanzyme in the presence of magnesium, adenosine monophosphate, and ribose-5-phosphate
Total Genus 434
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The genus trace: a function that shows values of genus (vertical axis) for subchains spanned between the first residue, and all other residues (shown on horizontal axis). The number of the latter residue and the genus of a given subchain are shown interactively.

Total Genus
434
sequence length
1444
structure length
1375
Chain Sequence
SVAAKTLLIENEDGKGSTRMEVQDFMKRFHMHASEDDKTGSPSTAWGTLRFPTKEATAPYLRLSVNDDPEDALLFVKAMLAQKYGETYDRPSLILSVTGGARNFTLPPRLETAIAKGLRLAAQRTNAWVVTGGTNTGVMKLTGQIMEALSKTQSHFIPPTIGIATYGVIIGGDDMTRGEPPKIGLEYEMHKKDPPKTTPLDDNHNLFLLVDDGSTNKFGKEIKFRAAFENAAGQAFAAPVVTIVVQGGPGTLGTALQAVRQGTPIVVVDGSGLAADVLAYAYNFMHNPLTRFKSYTIDDLRQKVAQTFNPKSSQQLTNLLDSALECVQDPNLVVVYSLQESGIDEFDDCILKAIFSSQGKLGNKLKQAMYFDQLDVAKRALSEASKNGQHNEIAACINDNLMAAMMHNKPHFVELYLGFDAKIYELKPSEEVAKTNITALDELPSFALAIEELYKREAKKPHSHVQRLVSLSNTDVLGRHYRGRDLANTRAYNVLRMDQIFARLVSKDFSVNRDFTIYDSKYDKVPGIQFRRTAQASHMLFLWAICLDRFRMARHFWLIGDQSIINALVASRILERLSTHRALQGPHLAEERAKMQHNAKKFEELAVGVLGECHGSDSHMASEMLHSKNDMFNKKNAINIAYDAKSLAFLSHPATQSVINADWYGHLKSVTSFWAVLFAFFFPFFVLPFINFSGAHRLRRKFAKFYSAPYTRFISDLLSHFVLCVVTSYFVLDKLEDTISAIEWILLVWFVALLLEELRQMIFCDGIAEYISDTWNRLDLIMITLFFVGFFTHASDPSNQDSKVVSKGIHAFLVVVLWLRFMRYYALSKNLGPKLIMMMEMMKDVSTFVFLLLIFLIGYGVAAQSLLSPDEDFSSRTFIGVLFRPYFQIYGELFLDDLNSEANCLGDTPFTECSRETVRMVPFFLAVYILGSNVLLVNLLIAMFNDTYMKVQEAAEDLWRKQNYELCAEYKDRPFLPAPFILLAHVHMLFMRLLRLCGVHTQEHEKIQDDETKRKITTFEELNTDKFLRRWERERQEMLEARVKMTNDNVVQAMGMMDQLLEHMISFRFSLDQQATKINRLNSAVAVHGHTAEAAEWYVPPEEYPKSGGVKRYLIDASMVPLSIMCPSYDPVEYTHPSVAAQPVWADPADPRKIKFNVKDEVNGKVVDRTSCHPSGISIDSNTGRPINPWGRTGMTGRGLLGKWGVNQAADTVVTRWKRSPDGSILERDGKKVLEFVAIQRQDNKMWAIPGGFVDNGEDVALTSGREFMEEALGMGTSADLMSAESKDSLAALFSSGTIVARIYCEDPRNTDNAWVETTCVNFHDESGRHAARLKLQGGDDAEHARWMMVHGGLNLFASHRTLLQHVTSALNAYF
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The genus matrix. At position (x,y) a genus value for a subchain spanned between x’th and y’th residue is shown. Values of the genus are represented by color, according to the scale given on the right.

Structure visualization

After clicking on a point (x,y) in the genus matrix above, a subchain from x to y is shown in color.

publication title Coupling enzymatic activity and gating in an ancient TRPM chanzyme and its molecular evolution
rcsb
molecule tags Transport protein
source organism Salpingoeca rosetta
molecule keywords TRPM2 Chanzyme
total genus 434
structure length 1375
sequence length 1444
chains with identical sequence B, C, D
ec nomenclature ec ?:
pdb deposition date 2023-05-05
Image from the rcsb pdb (www.rcsb.org)
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