8T81A

Influenza pan endonuclease e23k mutant with 6-(4-(1h-tetrazol-5-yl)-2-(trifluoromethyl)phenyl)-3-hydroxy-4-oxo-1,4-dihydropyridine-2-carboxylic acid
Total Genus 64
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The genus trace: a function that shows values of genus (vertical axis) for subchains spanned between the first residue, and all other residues (shown on horizontal axis). The number of the latter residue and the genus of a given subchain are shown interactively.

Total Genus
64
sequence length
184
structure length
174
Chain Sequence
SAMEDFVRQCFNPMIVELAEKAMKKYGEDPKIETNKFAAICTHLEVCFMYSDFHRFEIIEGRDRIMAWTVVNSICNTTGVEKPKFLPDLYDYKENRFIEIGVTRREVHIYYLEKANKIKSEKTHIHIFSFTGEEMATKADYTLDEESRARIKTRLFTIRQEMASRSLWDSFRQS
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The genus matrix. At position (x,y) a genus value for a subchain spanned between x’th and y’th residue is shown. Values of the genus are represented by color, according to the scale given on the right.

Structure visualization

After clicking on a point (x,y) in the genus matrix above, a subchain from x to y is shown in color.

publication title Structural Studies of Inhibitors with Clinically Relevant Influenza Endonuclease Variants.
pubmed doi rcsb
molecule tags Viral protein,hydrolase/inhibitor
source organism Influenza a virus
molecule keywords Polymerase acidic protein
total genus 64
structure length 174
sequence length 184
ec nomenclature
pdb deposition date 2023-06-21
Image from the rcsb pdb (www.rcsb.org)
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similar chains in the Genus database (?% sequence similarity)
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similar chains in the pdb database (?% sequence similarity)

 
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#similar chains, but unknotted
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