8TR1A

Crystal structure of trypanosome brucei hypoxanthine guanine phosphopribosyltransferase in complex with [2s,4r]-4-guanin-9-yl-2-(2- phosphonoethoxymethyl)-1-n-(3-phosphonopropionyl)pyrrolidine
Total Genus 57
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The genus trace: a function that shows values of genus (vertical axis) for subchains spanned between the first residue, and all other residues (shown on horizontal axis). The number of the latter residue and the genus of a given subchain are shown interactively.

Total Genus
57
sequence length
199
structure length
178
Chain Sequence
ACKYDFATSVLFTEAELHTRMRGVAQRIADDYSNCNLKPLENPLVIVSVLKGSFVFTADMVRILGDFGVPTRVEFLRCDIRGKHVLVLEDILDTALTLREVVDSLKKSEPASIKTLVAIDKPGGRKIPFTAEYVVADVPNVFVVGYGLDYDQSYREVRDVVILKPSVYETWGKELERR
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The genus matrix. At position (x,y) a genus value for a subchain spanned between x’th and y’th residue is shown. Values of the genus are represented by color, according to the scale given on the right.

Structure visualization

After clicking on a point (x,y) in the genus matrix above, a subchain from x to y is shown in color.

publication title Development of Prolinol Containing Inhibitors of Hypoxanthine-Guanine-Xanthine Phosphoribosyltransferase: Rational Structure-Based Drug Design.
pubmed doi rcsb
molecule tags Transferase
source organism Trypanosoma brucei
molecule keywords Hypoxanthine-guanine phosphoribosyltransferase
total genus 57
structure length 178
sequence length 199
chains with identical sequence B, C, D
ec nomenclature
pdb deposition date 2023-08-09
Image from the rcsb pdb (www.rcsb.org)
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similar chains in the Genus database (?% sequence similarity)
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similar chains in the pdb database (?% sequence similarity)

 
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#similar chains, but unknotted
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