8TZBA

Structure of the c-terminal half of lrrk2 bound to gzd-824 (i2020t mutant)
Total Genus 183
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The genus trace: a function that shows values of genus (vertical axis) for subchains spanned between the first residue, and all other residues (shown on horizontal axis). The number of the latter residue and the genus of a given subchain are shown interactively.

Total Genus
183
sequence length
1189
structure length
920
Chain Sequence
RMKLMIVGNSGKTTLLQQDVKDWPILVLNVWDFLYLAVYVDAMKPWLSPVILVGTHLDVEKQRKACMSKITKIRDYHFVNATEESDALAKLRKTIINESLNVELEKIILSERKNVPIDRKRLLQLVRENQLQLDENELPHALNESGVLLHALQLSDLYFWLCKIMQILTVPKNYMSQYFKLLEKFQIALPIPSSLSDHRPVIELPHCENSEIIIRLYEMPYFPMGFWSRLINRLLEISPYRPNRMYWRIYLNWSPEAYCLVGSEVLDNHPESFLKITVPSCRKGCILLGQVVDHIDSLMEEWFPGLLLKKWALYSFNDGEEHQKILLDDLMKKAEEGDLLVNPDQPRLTIPISQIAPDLILADLPRNIMLNNDELEFEQAPEFLLGDGSFGSVYRAAYEGEEVAVKIFNSLRLLRQELVVLCHLHHPSLISLLAAGIRPRMLVMELASKGSLDRLLQQDKASLTRTLQHRIALHVADGLRYLHSAMIIYRDLKPHNVLLFTLYPNAAIIAKIADYGPGFRAPEVYNQQADVYSFGLLLYDILTTGGRIVEKLPDPVKEYGCAPWPMVEKLIKQCLKENPQERPTSAQVFDILNSAELVCLTRRILLPKNVIVECMVATHASIWLGCGHTDRGQLSFLDLNTEGYTSEEVADSRILCLALVHLPVEKESWIVSGTQSGTLLVINTEDGKKRHTLEKMTDSVTCLYCNLLVGTADGKLAIFEDKTVKLKGAAPLKILNIGNVTPLMCLSESVMWGGCGTKIFSFSNDFTIQKLIETRTSQLFSYAAFSDSNIITVVVDTALYIAKQNSPVVEVWDKKTEKLIDCVHFLREVYSGRVKTLCLQALWIGTGGGHILLLDLSTRRLIRVICNSVRVMMTAQKNVMLVLGYNIQSCLTVWDINLPHEVQNLEKHIEVRKELAEKMR
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The genus matrix. At position (x,y) a genus value for a subchain spanned between x’th and y’th residue is shown. Values of the genus are represented by color, according to the scale given on the right.

Structure visualization

After clicking on a point (x,y) in the genus matrix above, a subchain from x to y is shown in color.

publication title Structure of the C-terminal half of LRRK2 bound to GZD-824 (I2020T mutant)
rcsb
molecule tags Protein binding
source organism Homo sapiens
molecule keywords Leucine-rich repeat serine/threonine-protein kinase 2
total genus 183
structure length 920
sequence length 1189
ec nomenclature ec 2.7.11.1: non-specific serine/threonine protein kinase.
pdb deposition date 2023-08-26
Image from the rcsb pdb (www.rcsb.org)
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similar chains in the Genus database (?% sequence similarity)
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similar chains in the pdb database (?% sequence similarity)

 
#similar chains in the Genus database (?% sequence similarity)
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#similar chains, but unknotted
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