9FIPA

Structure-guided discovery of selective usp7 inhibitors with in vivo activity
Total Genus 92
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The genus trace: a function that shows values of genus (vertical axis) for subchains spanned between the first residue, and all other residues (shown on horizontal axis). The number of the latter residue and the genus of a given subchain are shown interactively.

Total Genus
92
sequence length
344
structure length
330
Chain Sequence
TGYVGLKNQGATCYMNSLLQTLFFTNQLRKAVYMMPTEGDDSSKSVPLALQRVFYELQHSDKPVGTKKLTKSFGWETLDSFMQHDVQELCRVLLDNVENKMKGTCVEGTIPKLFRGKMVSYIQCKEVDYRSDRREDYYDIQLSIKGKKNIFESFVDYVAVEQLDGDNKYDAGEHGLQEAEKGVKFLTLPPVLHLQLMRFMYDPQNIKINDRFEFPEQLPLDEFLQKTDPKDPANYILHAVLVHSGDNHGGHYVVYLNPKGDGKWCKFDDDVVSRCTKEEAIEHNYGTNAYMLVYIRESKLSEVLQAVTDHDIPQQLVERLQEEKRIEAQK
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The genus matrix. At position (x,y) a genus value for a subchain spanned between x’th and y’th residue is shown. Values of the genus are represented by color, according to the scale given on the right.

Structure visualization

After clicking on a point (x,y) in the genus matrix above, a subchain from x to y is shown in color.

publication title Structure-Guided Discovery of Selective USP7 Inhibitors with In Vivo Activity.
pubmed doi rcsb
molecule keywords Ubiquitin carboxyl-terminal hydrolase 7
molecule tags Hydrolase
source organism Homo sapiens
total genus 92
structure length 330
sequence length 344
chains with identical sequence B
ec nomenclature ec 3.4.19.12: ubiquitinyl hydrolase 1.
pdb deposition date 2024-05-29
Image from the rcsb pdb (www.rcsb.org)
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similar chains in the Genus database (?% sequence similarity)
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similar chains in the pdb database (?% sequence similarity)

 
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