9MQ5A

Crystal structure shp2 tandem sh2 domains in complex with pzr doubly tyrosine phosphorylated itim peptide
Total Genus 52
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The genus trace: a function that shows values of genus (vertical axis) for subchains spanned between the first residue, and all other residues (shown on horizontal axis). The number of the latter residue and the genus of a given subchain are shown interactively.

Total Genus
52
sequence length
216
structure length
205
Chain Sequence
RRWFHPNITGVEAENLLLTRGVDGSFLARPSKSNPGDFTLSVRRNGAVTHIKIQNTGDYYDLYGGEKFATLAELVQYYMEHHGQLKEKNGDVIELKYPLNCADPTSERWFHGHLSGKEAEKLLTEKGKHGSFLVRESQSHPGDFVLSVRTSKVTHVMIRCQELKYDVGGGERFDSLTDLVEHYKKNPMVETLGTVLQLKQPLNTT
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The genus matrix. At position (x,y) a genus value for a subchain spanned between x’th and y’th residue is shown. Values of the genus are represented by color, according to the scale given on the right.

Structure visualization

After clicking on a point (x,y) in the genus matrix above, a subchain from x to y is shown in color.

publication title SHP2 genetic variants in NSML-associated RASopathies disrupt the PZR-IRX transcription factor signaling axis.
pubmed doi rcsb
molecule keywords Tyrosine-protein phosphatase non-receptor type 11
molecule tags Signaling protein
source organism Homo sapiens
total genus 52
structure length 205
sequence length 216
ec nomenclature ec 3.1.3.48: protein-tyrosine-phosphatase.
pdb deposition date 2025-01-02
Image from the rcsb pdb (www.rcsb.org)
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