1HTLA

Mutation of a buried residue causes lack of activity but no conformational change: crystal structure of e. coli heat-labile enterotoxin mutant val 97--> lys
Total Genus 44
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The genus trace: a function that shows values of genus (vertical axis) for subchains spanned between the first residue, and all other residues (shown on horizontal axis). The number of the latter residue and the genus of a given subchain are shown interactively.

Total Genus
44
sequence length
185
structure length
185
Chain Sequence
RLYRADSRPPDEIKRSGGLMPRGHNEYFDRGTQMNINLYDHARGTQTGFVRYDDGYVSTSLSLRSAHLAGQSILSGYSTYYIYVIATAPNMFNKNDVLGVYSPHPYEQEVSALGGIPYSQIYGWYRVNFGVIDERLHRNREYRDRYYRNLNIAPAEDGYRLAGFPPDHQAWREEPWIHHAPQGCG
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The genus matrix. At position (x,y) a genus value for a subchain spanned between x’th and y’th residue is shown. Values of the genus are represented by color, according to the scale given on the right.

Structure visualization

After clicking on a point (x,y) in the genus matrix above, a subchain from x to y is shown in color.

Chord Diagram
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molecule tags Enterotoxin
molecule keywords HEAT-LABILE ENTEROTOXIN, SUBUNIT B
publication title Mutation of a buried residue causes loss of activity but no conformational change in the heat-labile enterotoxin of Escherichia coli.
pubmed doi rcsb
source organism Escherichia coli
total genus 44
structure length 185
sequence length 185
ec nomenclature
pdb deposition date 1995-02-15
Image from the rcsb pdb (www.rcsb.org)
cath code
ClassArchitectureTopologyHomologyDomain
3.90.210.10 Alpha Beta Alpha-Beta Complex Heat-Labile Enterotoxin; Chain A Heat-Labile Enterotoxin, subunit A 1htlA00
1LTAA 1HTLA 2VSEA 1PRTA 4K6LG 1BCPA 1S5CA 1S5FA 4Z9CA 1XTCA 1S5EA 2A5DB 2CB4A 1TIIA 2VSAA 1LTSA 1S5BA 1LTBA 1S5DA 1LT4A 1LTTA 1LTGA 1PTOA 2CB6A 1LTIA 1LT3A 2A5FB 2A5GB
chains in the Genus database with same CATH superfamily
1LTAA 1HTLA 2VSEA 1PRTA 4K6LG 1BCPA 1S5CA 1S5FA 4Z9CA 1XTCA 1S5EA 2A5DB 2CB4A 1TIIA 2VSAA 1LTSA 1S5BA 1LTBA 1S5DA 1LT4A 1LTTA 1LTGA 1PTOA 2CB6A 1LTIA 1LT3A 2A5FB 2A5GB
chains in the Genus database with same CATH topology
1LTAA 1HTLA 2VSEA 1PRTA 4K6LG 1BCPA 1S5CA 1S5FA 4Z9CA 1XTCA 1S5EA 2A5DB 2CB4A 1TIIA 2VSAA 1LTSA 1S5BA 1LTBA 1S5DA 1LT4A 1LTTA 1LTGA 1PTOA 2CB6A 1LTIA 1LT3A 2A5FB 2A5GB
chains in the Genus database with same CATH homology


 
#chains in the Genus database with same CATH superfamily
 1LTA A;  1HTL A;  2VSE A;  1PRT A;  4K6L G;  1BCP A;  1S5C A;  1S5F A;  4Z9C A;  1XTC A;  1S5E A;  2A5D B;  2CB4 A;  1TII A;  2VSA A;  1LTS A;  1S5B A;  1LTB A;  1S5D A;  1LT4 A;  1LTT A;  1LTG A;  1PTO A;  2CB6 A;  1LTI A;  1LT3 A;  2A5F B;  2A5G B; 
#chains in the Genus database with same CATH topology
 1LTA A;  1HTL A;  2VSE A;  1PRT A;  4K6L G;  1BCP A;  1S5C A;  1S5F A;  4Z9C A;  1XTC A;  1S5E A;  2A5D B;  2CB4 A;  1TII A;  2VSA A;  1LTS A;  1S5B A;  1LTB A;  1S5D A;  1LT4 A;  1LTT A;  1LTG A;  1PTO A;  2CB6 A;  1LTI A;  1LT3 A;  2A5F B;  2A5G B; 
#chains in the Genus database with same CATH homology
 1LTA A;  1HTL A;  2VSE A;  1PRT A;  4K6L G;  1BCP A;  1S5C A;  1S5F A;  4Z9C A;  1XTC A;  1S5E A;  2A5D B;  2CB4 A;  1TII A;  2VSA A;  1LTS A;  1S5B A;  1LTB A;  1S5D A;  1LT4 A;  1LTT A;  1LTG A;  1PTO A;  2CB6 A;  1LTI A;  1LT3 A;  2A5F B;  2A5G B; 
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similar chains in the Genus database (?% sequence similarity)
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similar chains in the pdb database (?% sequence similarity)

 
#similar chains in the Genus database (?% sequence similarity)
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#similar chains, but unknotted
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#similar chains in the pdb database (?% sequence similarity)
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