1S2HA

The mad2 spindle checkpoint protein possesses two distinct natively folded states
Total Genus 38
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The genus trace: a function that shows values of genus (vertical axis) for subchains spanned between the first residue, and all other residues (shown on horizontal axis). The number of the latter residue and the genus of a given subchain are shown interactively.

Total Genus
38
sequence length
205
structure length
205
Chain Sequence
MALQLSREQGITLRGSAEIVAEFFSFGINSILYQRGIYPSETFTRVQKYGLTLLVTTDLELIKYLNNVVEQLKDWLYKCSVQKLVVVISNIESGEVLERWQFDIECDKTAKDDSAPREKSQKAIQDEIRSVIAQITATVTFLPLLEVSCSFDLLIYTDKDLVVPEKWEESGPQFITNSEEVRLRSFTTTIHKVNSMVAYKIPVND
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The genus matrix. At position (x,y) a genus value for a subchain spanned between x’th and y’th residue is shown. Values of the genus are represented by color, according to the scale given on the right.

Structure visualization

After clicking on a point (x,y) in the genus matrix above, a subchain from x to y is shown in color.

Chord Diagram
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molecule tags Cell cycle
molecule keywords Mitotic spindle assembly checkpoint protein MAD2A
publication title The Mad2 spindle checkpoint protein has two distinct natively folded states.
pubmed doi rcsb
source organism Homo sapiens
total genus 38
structure length 205
sequence length 205
ec nomenclature
pdb deposition date 2004-01-08

pfam database annotations

chain Pfam Accession Code Pfam Family Identifier Pfam Description
A PF02301 HORMA HORMA domain
Image from the rcsb pdb (www.rcsb.org)
cath code
ClassArchitectureTopologyHomologyDomain
3.30.900.10 Alpha Beta 2-Layer Sandwich Cell Cycle, Spindle Assembly Checkpoint Protein; Chain A HORMA domain 1s2hA00
1S2HA 1KLQA 5LCWZ 4GK0A 4TZNA 1GO4A 4EXTC 4TZLA 4TZSA 4GK5A 4TZJA 4YK8B 4FJOC 4J2GA 4AEZB 1DUJA 4TZQA 2V64A 4TRKA 2VFXA 3ABEC 3VU7C 4TZMA 5C50B 2V64D 2QYFA 3GMHA 3ABDA 4TZOA
chains in the Genus database with same CATH superfamily
1S2HA 1KLQA 5LCWZ 4GK0A 4TZNA 1GO4A 4EXTC 4TZLA 4TZSA 4GK5A 4TZJA 4YK8B 4FJOC 4J2GA 4AEZB 1DUJA 2V64A 4TRKA 4TZQA 2VFXA 3ABEC 3VU7C 4TZMA 5C50B 2V64D 2QYFA 2QYFB 3GMHA 3ABDA 4TZOA
chains in the Genus database with same CATH topology
1S2HA 1KLQA 5LCWZ 4GK0A 4TZNA 1GO4A 4EXTC 4TZLA 4TZSA 4GK5A 4TZJA 4YK8B 4FJOC 4J2GA 4AEZB 1DUJA 4TZQA 2V64A 4TRKA 2VFXA 3ABEC 3VU7C 4TZMA 5C50B 2V64D 2QYFA 3GMHA 3ABDA 4TZOA
chains in the Genus database with same CATH homology


 
#chains in the Genus database with same CATH superfamily
 1S2H A;  1KLQ A;  5LCW Z;  4GK0 A;  4TZN A;  1GO4 A;  4EXT C;  4TZL A;  4TZS A;  4GK5 A;  4TZJ A;  4YK8 B;  4FJO C;  4J2G A;  4AEZ B;  1DUJ A;  4TZQ A;  2V64 A;  4TRK A;  2VFX A;  3ABE C;  3VU7 C;  4TZM A;  5C50 B;  2V64 D;  2QYF A;  3GMH A;  3ABD A;  4TZO A; 
#chains in the Genus database with same CATH topology
 1S2H A;  1KLQ A;  5LCW Z;  4GK0 A;  4TZN A;  1GO4 A;  4EXT C;  4TZL A;  4TZS A;  4GK5 A;  4TZJ A;  4YK8 B;  4FJO C;  4J2G A;  4AEZ B;  1DUJ A;  2V64 A;  4TRK A;  4TZQ A;  2VFX A;  3ABE C;  3VU7 C;  4TZM A;  5C50 B;  2V64 D;  2QYF A;  2QYF B;  3GMH A;  3ABD A;  4TZO A; 
#chains in the Genus database with same CATH homology
 1S2H A;  1KLQ A;  5LCW Z;  4GK0 A;  4TZN A;  1GO4 A;  4EXT C;  4TZL A;  4TZS A;  4GK5 A;  4TZJ A;  4YK8 B;  4FJO C;  4J2G A;  4AEZ B;  1DUJ A;  4TZQ A;  2V64 A;  4TRK A;  2VFX A;  3ABE C;  3VU7 C;  4TZM A;  5C50 B;  2V64 D;  2QYF A;  3GMH A;  3ABD A;  4TZO A; 
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similar chains in the Genus database (?% sequence similarity)
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similar chains in the pdb database (?% sequence similarity)

 
#similar chains in the Genus database (?% sequence similarity)
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#similar chains, but unknotted
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