2VFXA

Structure of the symmetric mad2 dimer
Total Genus 57
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The genus trace: a function that shows values of genus (vertical axis) for subchains spanned between the first residue, and all other residues (shown on horizontal axis). The number of the latter residue and the genus of a given subchain are shown interactively.

Total Genus
57
sequence length
206
structure length
203
Chain Sequence
GMALQLSREQGITARGSAEIVAEFFSFGINSILYQRGIYPSETFTRVQKYGLTLLVTTDLELIKYLNNVVEQLKDWLYKSSVQKLVVVISNIESGEVLERWQFDIESDKTASAPREKSQKAIQDEIRSVIRQITATVTFLPLLEVSCSFDLLIYTDKDLVVPEKWEESGPQFITNSEEVRLRSFTTTIHKVNSMVAYKIPVND
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The genus matrix. At position (x,y) a genus value for a subchain spanned between x’th and y’th residue is shown. Values of the genus are represented by color, according to the scale given on the right.

Structure visualization

After clicking on a point (x,y) in the genus matrix above, a subchain from x to y is shown in color.

Chord Diagram
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molecule tags Cell cycle
molecule keywords MITOTIC SPINDLE ASSEMBLY CHECKPOINT PROTEIN MAD2A
publication title Insights Into MAD2 Regulation in the Spindle Checkpoint Revealed by the Crystal Structure of the Symmetric MAD2 Dimer.
pubmed doi rcsb
source organism Homo sapiens
total genus 57
structure length 203
sequence length 206
chains with identical sequence B, C, D, E, F, G, H, I, J, K, L
ec nomenclature
pdb deposition date 2007-11-05

pfam database annotations

chain Pfam Accession Code Pfam Family Identifier Pfam Description
A PF02301 HORMA HORMA domain
Image from the rcsb pdb (www.rcsb.org)
cath code
ClassArchitectureTopologyHomologyDomain
3.30.900.10 Alpha Beta 2-Layer Sandwich Cell Cycle, Spindle Assembly Checkpoint Protein; Chain A HORMA domain 2vfxA00
2V64D 3VU7C 4J2GA 5C50B 3ABDA 3ABEC 4EXTC 4TRKA 4TZOA 4GK5A 2QYFA 4AEZB 4FJOC 1S2HA 2VFXA 1DUJA 1GO4A 4GK0A 4TZQA 4TZJA 4TZMA 1KLQA 4TZSA 4YK8B 5LCWZ 4TZNA 4TZLA 2V64A 3GMHA
chains in the Genus database with same CATH superfamily
2V64D 3VU7C 4J2GA 5C50B 3ABDA 2QYFB 3ABEC 4EXTC 4TRKA 4TZOA 4GK5A 2QYFA 4AEZB 4FJOC 1S2HA 2VFXA 1DUJA 1GO4A 4GK0A 4TZQA 4TZJA 4TZMA 1KLQA 4TZSA 4YK8B 5LCWZ 4TZNA 4TZLA 2V64A 3GMHA
chains in the Genus database with same CATH topology
2V64D 3VU7C 4J2GA 5C50B 3ABDA 3ABEC 4EXTC 4TRKA 4TZOA 4GK5A 2QYFA 4AEZB 4FJOC 1S2HA 2VFXA 1DUJA 1GO4A 4GK0A 4TZQA 4TZJA 4TZMA 1KLQA 4TZSA 4YK8B 5LCWZ 4TZNA 4TZLA 2V64A 3GMHA
chains in the Genus database with same CATH homology


 
#chains in the Genus database with same CATH superfamily
 2V64 D;  3VU7 C;  4J2G A;  5C50 B;  3ABD A;  3ABE C;  4EXT C;  4TRK A;  4TZO A;  4GK5 A;  2QYF A;  4AEZ B;  4FJO C;  1S2H A;  2VFX A;  1DUJ A;  1GO4 A;  4GK0 A;  4TZQ A;  4TZJ A;  4TZM A;  1KLQ A;  4TZS A;  4YK8 B;  5LCW Z;  4TZN A;  4TZL A;  2V64 A;  3GMH A; 
#chains in the Genus database with same CATH topology
 2V64 D;  3VU7 C;  4J2G A;  5C50 B;  3ABD A;  2QYF B;  3ABE C;  4EXT C;  4TRK A;  4TZO A;  4GK5 A;  2QYF A;  4AEZ B;  4FJO C;  1S2H A;  2VFX A;  1DUJ A;  1GO4 A;  4GK0 A;  4TZQ A;  4TZJ A;  4TZM A;  1KLQ A;  4TZS A;  4YK8 B;  5LCW Z;  4TZN A;  4TZL A;  2V64 A;  3GMH A; 
#chains in the Genus database with same CATH homology
 2V64 D;  3VU7 C;  4J2G A;  5C50 B;  3ABD A;  3ABE C;  4EXT C;  4TRK A;  4TZO A;  4GK5 A;  2QYF A;  4AEZ B;  4FJO C;  1S2H A;  2VFX A;  1DUJ A;  1GO4 A;  4GK0 A;  4TZQ A;  4TZJ A;  4TZM A;  1KLQ A;  4TZS A;  4YK8 B;  5LCW Z;  4TZN A;  4TZL A;  2V64 A;  3GMH A; 
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similar chains in the Genus database (?% sequence similarity)
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similar chains in the pdb database (?% sequence similarity)

 
#similar chains in the Genus database (?% sequence similarity)
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#similar chains, but unknotted
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#similar chains in the pdb database (?% sequence similarity)
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