2HLFA

Structure of the escherichis coli clc chloride channel y445e mutant and fab complex
Total Genus 170
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The genus trace: a function that shows values of genus (vertical axis) for subchains spanned between the first residue, and all other residues (shown on horizontal axis). The number of the latter residue and the genus of a given subchain are shown interactively.

Total Genus
170
sequence length
444
structure length
444
Chain Sequence
RRRQLIRQLLERDKTPLAILFMAAVVGTLVGLAAVAFDKGVAWLQNQRMGALVHTADNYPLLLTVAFLCSAVLAMFGYFLVRKYAPEAGGSGIPEIEGALEDQRPVRWWRVLPVKFFGGLGTLGGGMVLGREGPTVQIGGNIGRMVLDIFRLKGDEARHTLLATGAAAGLAAAFNAPLAGILFIIEEMRPQFRYTLISIKAVFIGVIMSTIMYRIFNHEVALIDVGKLSDAPLNTLWLYLILGIIFGIFGPIFNKWVLGMQDLLHRVHGGNITKWVLMGGAIGGLCGLLGFVAPATSGGGFNLIPIATAGNFSMGMLVFIFVARVITTLLCFSSGAPGGIFAPMLALGTVLGTAFGMVAVELFPQYHLEAGTFAIAGMGALLAASIRAPLTGIILVLEMTDNYQLILPMIITGLGATLLAQFTGGKPLESAILARTLAKQEAEQ
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The genus matrix. At position (x,y) a genus value for a subchain spanned between x’th and y’th residue is shown. Values of the genus are represented by color, according to the scale given on the right.

Structure visualization

After clicking on a point (x,y) in the genus matrix above, a subchain from x to y is shown in color.

Chord Diagram
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molecule tags Proton transport,membrane protein
molecule keywords H(+)/Cl(-) exchange transporter clcA
publication title Synergism Between Halide Binding and Proton Transport in a CLC-type Exchanger
pubmed doi rcsb
source organism Escherichia coli
total genus 170
structure length 444
sequence length 444
chains with identical sequence B
ec nomenclature
pdb deposition date 2006-07-07

pfam database annotations

chain Pfam Accession Code Pfam Family Identifier Pfam Description
A PF00654 Voltage_CLC Voltage gated chloride channel
Image from the rcsb pdb (www.rcsb.org)
cath code
ClassArchitectureTopologyHomologyDomain
1.10.3080.10 Mainly Alpha Orthogonal Bundle Clc chloride channel Clc chloride channel 2hlfA00
2EXYA 2FECA 3DETA 2HT3A 1OTTA 4KJPA 2HLFA 4KKAA 4FG6A 4ENEA 4FTPA 4KKLA 4KKBA 1OTSA 3EJZA 3NMOA 3ORGA 4KK8A 2HTKA 3Q17A 4KJQA 2EZ0A 2EXWA 4KK6A 5HD8A 3EJYA 4MQXA 4LOUA 2HT2A 2R9HA 4KJWA 4KKCA 2HTLA 1KPKA 1OTUA 2FEDA 2FEEA 2HT4A 3ND0A 4KK5A 2H2SA 4KK9A 1KPLA 2H2PA
chains in the Genus database with same CATH superfamily
2EXYA 2FECA 3DETA 2HT3A 1OTTA 4KJPA 2HLFA 4KKAA 4FG6A 4ENEA 4FTPA 4KKLA 4KKBA 1OTSA 3EJZA 3NMOA 3ORGA 4KK8A 2HTKA 3Q17A 4KJQA 2EZ0A 2EXWA 4KK6A 5HD8A 3EJYA 4MQXA 4LOUA 2HT2A 2R9HA 4KJWA 4KKCA 2HTLA 1KPKA 1OTUA 2FEDA 2FEEA 2HT4A 3ND0A 4KK5A 2H2SA 4KK9A 1KPLA 2H2PA
chains in the Genus database with same CATH topology
2EXYA 2FECA 3DETA 2HT3A 1OTTA 4KJPA 2HLFA 4KKAA 4FG6A 4ENEA 4FTPA 4KKLA 4KKBA 1OTSA 3EJZA 3NMOA 3ORGA 4KK8A 2HTKA 3Q17A 4KJQA 2EZ0A 2EXWA 4KK6A 5HD8A 3EJYA 4MQXA 4LOUA 2HT2A 2R9HA 4KJWA 4KKCA 2HTLA 1KPKA 1OTUA 2FEDA 2FEEA 2HT4A 3ND0A 4KK5A 2H2SA 4KK9A 1KPLA 2H2PA
chains in the Genus database with same CATH homology


 
#chains in the Genus database with same CATH superfamily
 2EXY A;  2FEC A;  3DET A;  2HT3 A;  1OTT A;  4KJP A;  2HLF A;  4KKA A;  4FG6 A;  4ENE A;  4FTP A;  4KKL A;  4KKB A;  1OTS A;  3EJZ A;  3NMO A;  3ORG A;  4KK8 A;  2HTK A;  3Q17 A;  4KJQ A;  2EZ0 A;  2EXW A;  4KK6 A;  5HD8 A;  3EJY A;  4MQX A;  4LOU A;  2HT2 A;  2R9H A;  4KJW A;  4KKC A;  2HTL A;  1KPK A;  1OTU A;  2FED A;  2FEE A;  2HT4 A;  3ND0 A;  4KK5 A;  2H2S A;  4KK9 A;  1KPL A;  2H2P A; 
#chains in the Genus database with same CATH topology
 2EXY A;  2FEC A;  3DET A;  2HT3 A;  1OTT A;  4KJP A;  2HLF A;  4KKA A;  4FG6 A;  4ENE A;  4FTP A;  4KKL A;  4KKB A;  1OTS A;  3EJZ A;  3NMO A;  3ORG A;  4KK8 A;  2HTK A;  3Q17 A;  4KJQ A;  2EZ0 A;  2EXW A;  4KK6 A;  5HD8 A;  3EJY A;  4MQX A;  4LOU A;  2HT2 A;  2R9H A;  4KJW A;  4KKC A;  2HTL A;  1KPK A;  1OTU A;  2FED A;  2FEE A;  2HT4 A;  3ND0 A;  4KK5 A;  2H2S A;  4KK9 A;  1KPL A;  2H2P A; 
#chains in the Genus database with same CATH homology
 2EXY A;  2FEC A;  3DET A;  2HT3 A;  1OTT A;  4KJP A;  2HLF A;  4KKA A;  4FG6 A;  4ENE A;  4FTP A;  4KKL A;  4KKB A;  1OTS A;  3EJZ A;  3NMO A;  3ORG A;  4KK8 A;  2HTK A;  3Q17 A;  4KJQ A;  2EZ0 A;  2EXW A;  4KK6 A;  5HD8 A;  3EJY A;  4MQX A;  4LOU A;  2HT2 A;  2R9H A;  4KJW A;  4KKC A;  2HTL A;  1KPK A;  1OTU A;  2FED A;  2FEE A;  2HT4 A;  3ND0 A;  4KK5 A;  2H2S A;  4KK9 A;  1KPL A;  2H2P A; 
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similar chains in the Genus database (?% sequence similarity)
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similar chains in the pdb database (?% sequence similarity)

 
#similar chains in the Genus database (?% sequence similarity)
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#similar chains, but unknotted
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