4KK8A

Structure of the e148q mutant of clc-ec1 deltanc construct in 100mm fluoride
Total Genus 176
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The genus trace: a function that shows values of genus (vertical axis) for subchains spanned between the first residue, and all other residues (shown on horizontal axis). The number of the latter residue and the genus of a given subchain are shown interactively.

Total Genus
176
sequence length
442
structure length
442
Chain Sequence
RRRQLIRQLLERDKTPLAILFMAAVVGTLVGLAAVAFDKGVAWLQNQRMGALVHTADNYPLLLTVAFLCSAVLAMFGYFLVRKYAPEAGGSGIPEIEGALEDQRPVRWWRVLPVKFFGGLGTLGGGMVLGRQGPTVQIGGNIGRMVLDIFRLKGDEARHTLLATGAAAGLAAAFNAPLAGILFIIEEMRPQFRYTLISIKAVFIGVIMSTIMYRIFNHEVALIDVGKLSDAPLNTLWLYLILGIIFGIFGPIFNKWVLGMQDLLHRVHGGNITKWVLMGGAIGGLCGLLGFVAPATSGGGFNLIPIATAGNFSMGMLVFIFVARVITTLLCFSSGAPGGIFAPMLALGTVLGTAFGMVAVELFPQYHLEAGTFAIAGMGALLAASIRAPLTGIILVLEMTDNYQLILPMIITGLGATLLAQFTGGKPLYSAILARTLAKQEA
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The genus matrix. At position (x,y) a genus value for a subchain spanned between x’th and y’th residue is shown. Values of the genus are represented by color, according to the scale given on the right.

Structure visualization

After clicking on a point (x,y) in the genus matrix above, a subchain from x to y is shown in color.

Chord Diagram
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molecule tags Transport protein
molecule keywords H(+)/Cl(-) exchange transporter ClcA
publication title Fluoride-dependent interruption of the transport cycle of a CLC Cl(-)/H(+) antiporter.
pubmed doi rcsb
source organism Escherichia coli
total genus 176
structure length 442
sequence length 442
chains with identical sequence B
ec nomenclature
pdb deposition date 2013-05-05

pfam database annotations

chain Pfam Accession Code Pfam Family Identifier Pfam Description
A PF00654 Voltage_CLC Voltage gated chloride channel
Image from the rcsb pdb (www.rcsb.org)
cath code
ClassArchitectureTopologyHomologyDomain
1.10.3080.10 Mainly Alpha Orthogonal Bundle Clc chloride channel Clc chloride channel 4kk8A00
3ORGA 2HT3A 2FEEA 4KKLA 3ND0A 3EJYA 4KK6A 5HD8A 4KKAA 1OTTA 1OTUA 4FG6A 4KJWA 2H2PA 2HTKA 4MQXA 4ENEA 2EXWA 2FEDA 2HT2A 3EJZA 3Q17A 4KK8A 1OTSA 2HLFA 3NMOA 1KPKA 2EXYA 4KKCA 2HT4A 2H2SA 2R9HA 3DETA 4KK9A 4KKBA 4LOUA 1KPLA 4KK5A 4KJQA 4FTPA 2HTLA 2FECA 4KJPA 2EZ0A
chains in the Genus database with same CATH superfamily
3ORGA 2HT3A 2FEEA 4KKLA 3ND0A 3EJYA 4KK6A 5HD8A 4KKAA 1OTTA 1OTUA 4FG6A 4KJWA 2H2PA 2HTKA 4MQXA 4ENEA 2EXWA 2FEDA 2HT2A 3EJZA 3Q17A 4KK8A 1OTSA 2HLFA 3NMOA 1KPKA 2EXYA 4KKCA 2HT4A 2H2SA 2R9HA 3DETA 4KK9A 4KKBA 4LOUA 1KPLA 4KK5A 4KJQA 4FTPA 2HTLA 2FECA 4KJPA 2EZ0A
chains in the Genus database with same CATH topology
3ORGA 2HT3A 2FEEA 4KKLA 3ND0A 3EJYA 4KK6A 5HD8A 4KKAA 1OTTA 1OTUA 4FG6A 4KJWA 2H2PA 2HTKA 4MQXA 4ENEA 2EXWA 2FEDA 2HT2A 3EJZA 3Q17A 4KK8A 1OTSA 2HLFA 3NMOA 1KPKA 2EXYA 4KKCA 2HT4A 2H2SA 2R9HA 3DETA 4KK9A 4KKBA 4LOUA 1KPLA 4KK5A 4KJQA 4FTPA 2HTLA 2FECA 4KJPA 2EZ0A
chains in the Genus database with same CATH homology


 
#chains in the Genus database with same CATH superfamily
 3ORG A;  2HT3 A;  2FEE A;  4KKL A;  3ND0 A;  3EJY A;  4KK6 A;  5HD8 A;  4KKA A;  1OTT A;  1OTU A;  4FG6 A;  4KJW A;  2H2P A;  2HTK A;  4MQX A;  4ENE A;  2EXW A;  2FED A;  2HT2 A;  3EJZ A;  3Q17 A;  4KK8 A;  1OTS A;  2HLF A;  3NMO A;  1KPK A;  2EXY A;  4KKC A;  2HT4 A;  2H2S A;  2R9H A;  3DET A;  4KK9 A;  4KKB A;  4LOU A;  1KPL A;  4KK5 A;  4KJQ A;  4FTP A;  2HTL A;  2FEC A;  4KJP A;  2EZ0 A; 
#chains in the Genus database with same CATH topology
 3ORG A;  2HT3 A;  2FEE A;  4KKL A;  3ND0 A;  3EJY A;  4KK6 A;  5HD8 A;  4KKA A;  1OTT A;  1OTU A;  4FG6 A;  4KJW A;  2H2P A;  2HTK A;  4MQX A;  4ENE A;  2EXW A;  2FED A;  2HT2 A;  3EJZ A;  3Q17 A;  4KK8 A;  1OTS A;  2HLF A;  3NMO A;  1KPK A;  2EXY A;  4KKC A;  2HT4 A;  2H2S A;  2R9H A;  3DET A;  4KK9 A;  4KKB A;  4LOU A;  1KPL A;  4KK5 A;  4KJQ A;  4FTP A;  2HTL A;  2FEC A;  4KJP A;  2EZ0 A; 
#chains in the Genus database with same CATH homology
 3ORG A;  2HT3 A;  2FEE A;  4KKL A;  3ND0 A;  3EJY A;  4KK6 A;  5HD8 A;  4KKA A;  1OTT A;  1OTU A;  4FG6 A;  4KJW A;  2H2P A;  2HTK A;  4MQX A;  4ENE A;  2EXW A;  2FED A;  2HT2 A;  3EJZ A;  3Q17 A;  4KK8 A;  1OTS A;  2HLF A;  3NMO A;  1KPK A;  2EXY A;  4KKC A;  2HT4 A;  2H2S A;  2R9H A;  3DET A;  4KK9 A;  4KKB A;  4LOU A;  1KPL A;  4KK5 A;  4KJQ A;  4FTP A;  2HTL A;  2FEC A;  4KJP A;  2EZ0 A; 
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similar chains in the Genus database (?% sequence similarity)
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similar chains in the pdb database (?% sequence similarity)

 
#similar chains in the Genus database (?% sequence similarity)
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#similar chains, but unknotted
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