2HT4A

Structure of the escherichia coli clc chloride channel y445w mutant and fab complex
Total Genus 177
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The genus trace: a function that shows values of genus (vertical axis) for subchains spanned between the first residue, and all other residues (shown on horizontal axis). The number of the latter residue and the genus of a given subchain are shown interactively.

Total Genus
177
sequence length
444
structure length
444
Chain Sequence
RRRQLIRQLLERDKTPLAILFMAAVVGTLVGLAAVAFDKGVAWLQNQRMGALVHTADNYPLLLTVAFLCSAVLAMFGYFLVRKYAPEAGGSGIPEIEGALEDQRPVRWWRVLPVKFFGGLGTLGGGMVLGREGPTVQIGGNIGRMVLDIFRLKGDEARHTLLATGAAAGLAAAFNAPLAGILFIIEEMRPQFRYTLISIKAVFIGVIMSTIMYRIFNHEVALIDVGKLSDAPLNTLWLYLILGIIFGIFGPIFNKWVLGMQDLLHRVHGGNITKWVLMGGAIGGLCGLLGFVAPATSGGGFNLIPIATAGNFSMGMLVFIFVARVITTLLCFSSGAPGGIFAPMLALGTVLGTAFGMVAVELFPQYHLEAGTFAIAGMGALLAASIRAPLTGIILVLEMTDNYQLILPMIITGLGATLLAQFTGGKPLWSAILARTLAKQEAEQ
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The genus matrix. At position (x,y) a genus value for a subchain spanned between x’th and y’th residue is shown. Values of the genus are represented by color, according to the scale given on the right.

Structure visualization

After clicking on a point (x,y) in the genus matrix above, a subchain from x to y is shown in color.

Chord Diagram
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molecule tags Membrane protein
molecule keywords H(+)/Cl(-) exchange transporter clcA
publication title Synergism Between Halide Binding and Proton Transport in a CLC-type Exchanger.
pubmed doi rcsb
source organism Escherichia coli
total genus 177
structure length 444
sequence length 444
chains with identical sequence B
ec nomenclature
pdb deposition date 2006-07-25

pfam database annotations

chain Pfam Accession Code Pfam Family Identifier Pfam Description
A PF00654 Voltage_CLC Voltage gated chloride channel
Image from the rcsb pdb (www.rcsb.org)
cath code
ClassArchitectureTopologyHomologyDomain
1.10.3080.10 Mainly Alpha Orthogonal Bundle Clc chloride channel Clc chloride channel 2ht4A00
4LOUA 2H2SA 4KK8A 1OTSA 3ND0A 3Q17A 2R9HA 2FEDA 2H2PA 4KKBA 1KPLA 3NMOA 4FG6A 4MQXA 3ORGA 3EJYA 2EXYA 1OTUA 2FEEA 2HLFA 4KKAA 4KKCA 2EZ0A 4KJWA 2EXWA 4FTPA 1OTTA 2HTKA 4KKLA 5HD8A 1KPKA 2HT2A 3EJZA 4KK6A 2HT3A 4ENEA 2FECA 2HT4A 3DETA 4KK9A 4KJPA 2HTLA 4KJQA 4KK5A
chains in the Genus database with same CATH superfamily
4LOUA 2H2SA 4KK8A 1OTSA 3ND0A 3Q17A 2R9HA 2FEDA 2H2PA 4KKBA 1KPLA 3NMOA 4FG6A 4MQXA 3ORGA 3EJYA 2EXYA 1OTUA 2FEEA 2HLFA 4KKAA 4KKCA 2EZ0A 4KJWA 2EXWA 4FTPA 1OTTA 2HTKA 4KKLA 5HD8A 1KPKA 2HT2A 3EJZA 4KK6A 2HT3A 4ENEA 2FECA 2HT4A 3DETA 4KK9A 4KJPA 2HTLA 4KJQA 4KK5A
chains in the Genus database with same CATH topology
4LOUA 2H2SA 4KK8A 1OTSA 3ND0A 3Q17A 2R9HA 2FEDA 2H2PA 4KKBA 1KPLA 3NMOA 4FG6A 4MQXA 3ORGA 3EJYA 2EXYA 1OTUA 2FEEA 2HLFA 4KKAA 4KKCA 2EZ0A 4KJWA 2EXWA 4FTPA 1OTTA 2HTKA 4KKLA 5HD8A 1KPKA 2HT2A 3EJZA 4KK6A 2HT3A 4ENEA 2FECA 2HT4A 3DETA 4KK9A 4KJPA 2HTLA 4KJQA 4KK5A
chains in the Genus database with same CATH homology


 
#chains in the Genus database with same CATH superfamily
 4LOU A;  2H2S A;  4KK8 A;  1OTS A;  3ND0 A;  3Q17 A;  2R9H A;  2FED A;  2H2P A;  4KKB A;  1KPL A;  3NMO A;  4FG6 A;  4MQX A;  3ORG A;  3EJY A;  2EXY A;  1OTU A;  2FEE A;  2HLF A;  4KKA A;  4KKC A;  2EZ0 A;  4KJW A;  2EXW A;  4FTP A;  1OTT A;  2HTK A;  4KKL A;  5HD8 A;  1KPK A;  2HT2 A;  3EJZ A;  4KK6 A;  2HT3 A;  4ENE A;  2FEC A;  2HT4 A;  3DET A;  4KK9 A;  4KJP A;  2HTL A;  4KJQ A;  4KK5 A; 
#chains in the Genus database with same CATH topology
 4LOU A;  2H2S A;  4KK8 A;  1OTS A;  3ND0 A;  3Q17 A;  2R9H A;  2FED A;  2H2P A;  4KKB A;  1KPL A;  3NMO A;  4FG6 A;  4MQX A;  3ORG A;  3EJY A;  2EXY A;  1OTU A;  2FEE A;  2HLF A;  4KKA A;  4KKC A;  2EZ0 A;  4KJW A;  2EXW A;  4FTP A;  1OTT A;  2HTK A;  4KKL A;  5HD8 A;  1KPK A;  2HT2 A;  3EJZ A;  4KK6 A;  2HT3 A;  4ENE A;  2FEC A;  2HT4 A;  3DET A;  4KK9 A;  4KJP A;  2HTL A;  4KJQ A;  4KK5 A; 
#chains in the Genus database with same CATH homology
 4LOU A;  2H2S A;  4KK8 A;  1OTS A;  3ND0 A;  3Q17 A;  2R9H A;  2FED A;  2H2P A;  4KKB A;  1KPL A;  3NMO A;  4FG6 A;  4MQX A;  3ORG A;  3EJY A;  2EXY A;  1OTU A;  2FEE A;  2HLF A;  4KKA A;  4KKC A;  2EZ0 A;  4KJW A;  2EXW A;  4FTP A;  1OTT A;  2HTK A;  4KKL A;  5HD8 A;  1KPK A;  2HT2 A;  3EJZ A;  4KK6 A;  2HT3 A;  4ENE A;  2FEC A;  2HT4 A;  3DET A;  4KK9 A;  4KJP A;  2HTL A;  4KJQ A;  4KK5 A; 
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similar chains in the Genus database (?% sequence similarity)
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similar chains in the pdb database (?% sequence similarity)

 
#similar chains in the Genus database (?% sequence similarity)
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#similar chains, but unknotted
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