4KKAA

Structure of the e148a mutant of clc-ec1 deltanc construct in 100mm fluoride and 20mm bromide
Total Genus 174
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The genus trace: a function that shows values of genus (vertical axis) for subchains spanned between the first residue, and all other residues (shown on horizontal axis). The number of the latter residue and the genus of a given subchain are shown interactively.

Total Genus
174
sequence length
443
structure length
443
Chain Sequence
RRRQLIRQLLERDKTPLAILFMAAVVGTLVGLAAVAFDKGVAWLQNQRMGALVHTADNYPLLLTVAFLCSAVLAMFGYFLVRKYAPEAGGSGIPEIEGALEDQRPVRWWRVLPVKFFGGLGTLGGGMVLGRAGPTVQIGGNIGRMVLDIFRLKGDEARHTLLATGAAAGLAAAFNAPLAGILFIIEEMRPQFRYTLISIKAVFIGVIMSTIMYRIFNHEVALIDVGKLSDAPLNTLWLYLILGIIFGIFGPIFNKWVLGMQDLLHRVHGGNITKWVLMGGAIGGLCGLLGFVAPATSGGGFNLIPIATAGNFSMGMLVFIFVARVITTLLCFSSGAPGGIFAPMLALGTVLGTAFGMVAVELFPQYHLEAGTFAIAGMGALLAASIRAPLTGIILVLEMTDNYQLILPMIITGLGATLLAQFTGGKPLYSAILARTLAKQEAE
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The genus matrix. At position (x,y) a genus value for a subchain spanned between x’th and y’th residue is shown. Values of the genus are represented by color, according to the scale given on the right.

Structure visualization

After clicking on a point (x,y) in the genus matrix above, a subchain from x to y is shown in color.

Chord Diagram
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molecule tags Transport protein
molecule keywords H(+)/Cl(-) exchange transporter ClcA
publication title Fluoride-dependent interruption of the transport cycle of a CLC Cl(-)/H(+) antiporter.
pubmed doi rcsb
source organism Escherichia coli
total genus 174
structure length 443
sequence length 443
chains with identical sequence B
ec nomenclature
pdb deposition date 2013-05-05

pfam database annotations

chain Pfam Accession Code Pfam Family Identifier Pfam Description
A PF00654 Voltage_CLC Voltage gated chloride channel
Image from the rcsb pdb (www.rcsb.org)
cath code
ClassArchitectureTopologyHomologyDomain
1.10.3080.10 Mainly Alpha Orthogonal Bundle Clc chloride channel Clc chloride channel 4kkaA00
3EJYA 2EXYA 4FG6A 2HT3A 2HT2A 4KK9A 1OTSA 3ND0A 5HD8A 1KPLA 2FEEA 2HLFA 1OTUA 2H2PA 1KPKA 2R9HA 3DETA 4KJQA 4KK8A 4KJWA 2HTKA 2H2SA 4KKCA 4LOUA 3Q17A 1OTTA 2EXWA 4KK6A 2FECA 2EZ0A 4KKLA 4KKAA 3NMOA 4MQXA 4KKBA 2FEDA 4FTPA 3ORGA 4KJPA 4KK5A 3EJZA 2HT4A 4ENEA 2HTLA
chains in the Genus database with same CATH superfamily
3EJYA 2EXYA 4FG6A 2HT3A 2HT2A 4KK9A 1OTSA 3ND0A 5HD8A 1KPLA 2FEEA 2HLFA 1OTUA 2H2PA 1KPKA 2R9HA 3DETA 4KJQA 4KK8A 4KJWA 2HTKA 2H2SA 4KKCA 4LOUA 3Q17A 1OTTA 2EXWA 4KK6A 2FECA 2EZ0A 4KKLA 4KKAA 3NMOA 4MQXA 4KKBA 2FEDA 4FTPA 3ORGA 4KJPA 4KK5A 3EJZA 2HT4A 4ENEA 2HTLA
chains in the Genus database with same CATH topology
3EJYA 2EXYA 4FG6A 2HT3A 2HT2A 4KK9A 1OTSA 3ND0A 5HD8A 1KPLA 2FEEA 2HLFA 1OTUA 2H2PA 1KPKA 2R9HA 3DETA 4KJQA 4KK8A 4KJWA 2HTKA 2H2SA 4KKCA 4LOUA 3Q17A 1OTTA 2EXWA 4KK6A 2FECA 2EZ0A 4KKLA 4KKAA 3NMOA 4MQXA 4KKBA 2FEDA 4FTPA 3ORGA 4KJPA 4KK5A 3EJZA 2HT4A 4ENEA 2HTLA
chains in the Genus database with same CATH homology


 
#chains in the Genus database with same CATH superfamily
 3EJY A;  2EXY A;  4FG6 A;  2HT3 A;  2HT2 A;  4KK9 A;  1OTS A;  3ND0 A;  5HD8 A;  1KPL A;  2FEE A;  2HLF A;  1OTU A;  2H2P A;  1KPK A;  2R9H A;  3DET A;  4KJQ A;  4KK8 A;  4KJW A;  2HTK A;  2H2S A;  4KKC A;  4LOU A;  3Q17 A;  1OTT A;  2EXW A;  4KK6 A;  2FEC A;  2EZ0 A;  4KKL A;  4KKA A;  3NMO A;  4MQX A;  4KKB A;  2FED A;  4FTP A;  3ORG A;  4KJP A;  4KK5 A;  3EJZ A;  2HT4 A;  4ENE A;  2HTL A; 
#chains in the Genus database with same CATH topology
 3EJY A;  2EXY A;  4FG6 A;  2HT3 A;  2HT2 A;  4KK9 A;  1OTS A;  3ND0 A;  5HD8 A;  1KPL A;  2FEE A;  2HLF A;  1OTU A;  2H2P A;  1KPK A;  2R9H A;  3DET A;  4KJQ A;  4KK8 A;  4KJW A;  2HTK A;  2H2S A;  4KKC A;  4LOU A;  3Q17 A;  1OTT A;  2EXW A;  4KK6 A;  2FEC A;  2EZ0 A;  4KKL A;  4KKA A;  3NMO A;  4MQX A;  4KKB A;  2FED A;  4FTP A;  3ORG A;  4KJP A;  4KK5 A;  3EJZ A;  2HT4 A;  4ENE A;  2HTL A; 
#chains in the Genus database with same CATH homology
 3EJY A;  2EXY A;  4FG6 A;  2HT3 A;  2HT2 A;  4KK9 A;  1OTS A;  3ND0 A;  5HD8 A;  1KPL A;  2FEE A;  2HLF A;  1OTU A;  2H2P A;  1KPK A;  2R9H A;  3DET A;  4KJQ A;  4KK8 A;  4KJW A;  2HTK A;  2H2S A;  4KKC A;  4LOU A;  3Q17 A;  1OTT A;  2EXW A;  4KK6 A;  2FEC A;  2EZ0 A;  4KKL A;  4KKA A;  3NMO A;  4MQX A;  4KKB A;  2FED A;  4FTP A;  3ORG A;  4KJP A;  4KK5 A;  3EJZ A;  2HT4 A;  4ENE A;  2HTL A; 
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similar chains in the Genus database (?% sequence similarity)
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similar chains in the pdb database (?% sequence similarity)

 
#similar chains in the Genus database (?% sequence similarity)
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#similar chains, but unknotted
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