2MUBA

Solution structure of the analgesic sea anemone peptide apetx2
Total Genus 2
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The genus trace: a function that shows values of genus (vertical axis) for subchains spanned between the first residue, and all other residues (shown on horizontal axis). The number of the latter residue and the genus of a given subchain are shown interactively.

Total Genus
2
sequence length
42
structure length
42
Chain Sequence
GTACSCGNSKGIYWFYRPSCPTDRGYTGSCRYFLGTCCTPAD
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The genus matrix. At position (x,y) a genus value for a subchain spanned between x’th and y’th residue is shown. Values of the genus are represented by color, according to the scale given on the right.

Structure visualization

After clicking on a point (x,y) in the genus matrix above, a subchain from x to y is shown in color.

Chord Diagram
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molecule tags Toxin
molecule keywords Toxin APETx2
publication title Understanding the Molecular Basis of Toxin Promiscuity: The Analgesic Sea Anemone Peptide APETx2 Interacts with Acid-Sensing Ion Channel 3 and hERG Channels via Overlapping Pharmacophores.
pubmed doi rcsb
total genus 2
structure length 42
sequence length 42
ec nomenclature
pdb deposition date 2014-09-07

pfam database annotations

chain Pfam Accession Code Pfam Family Identifier Pfam Description
A PF07936 Defensin_4 Potassium-channel blocking toxin
Image from the rcsb pdb (www.rcsb.org)
cath code
ClassArchitectureTopologyHomologyDomain
2.20.20.10 Mainly Beta Single Sheet Anthopleurin-A Anthopleurin-A 2mubA00
1ATXA 1APFA 2MN3A 2RNGA 1WQKA 3LMSB 1ZUFA 1AHLA 4GV5A 1Z99A 2SH1A 1WXNA 1ZLHB 2JTOA 3D4UB 1ZUEA 1SHIA 2MUBA 2H9XA 1ZLIB 1BDSA 1SH1A 1H5OA 1B8WA 2BDSA 2K2XA 1D6BA
chains in the Genus database with same CATH superfamily
1ATXA 2HJEA 1APFA 2MN3A 3KEZA 2RNGA 1WQKA 1GL9B 3LMSB 1ZUFA 1AHLA 4GV5A 1Z99A 3C38A 3IF4A 2SH1A 2DLAA 1GKUB 1ZHHB 1WXNA 1ZLHB 2IKDA 2JTOA 2QSFA 3D4UB 3C30A 1ZUEA 1SHIA 2MUBA 2QSGA 2H9XA 2IKEA 1ZLIB 2B9KA 1BDSA 1SH1A 2JR3A 1EL6A 3MYVA 1H5OA 2QSHA 4YIRA 3MCXA 2BDSA 2K2XA 2XXLA 1B8WA 1D6BA 2HJ9C
chains in the Genus database with same CATH topology
1ATXA 2HJEA 1APFA 2MN3A 3KEZA 2RNGA 1WQKA 3LMSB 1ZUFA 1AHLA 4GV5A 1Z99A 3C38A 2SH1A 2DLAA 1ZHHB 1WXNA 1ZLHB 2IKDA 2JTOA 2QSFA 3D4UB 3C30A 1ZUEA 1SHIA 2MUBA 2QSGA 2H9XA 2IKEA 1ZLIB 2B9KA 1BDSA 1SH1A 2JR3A 1H5OA 3MYVA 2QSHA 4YIRA 3MCXA 2BDSA 2K2XA 2XXLA 1B8WA 1D6BA 2HJ9C
chains in the Genus database with same CATH homology


 
#chains in the Genus database with same CATH superfamily
 1ATX A;  1APF A;  2MN3 A;  2RNG A;  1WQK A;  3LMS B;  1ZUF A;  1AHL A;  4GV5 A;  1Z99 A;  2SH1 A;  1WXN A;  1ZLH B;  2JTO A;  3D4U B;  1ZUE A;  1SHI A;  2MUB A;  2H9X A;  1ZLI B;  1BDS A;  1SH1 A;  1H5O A;  1B8W A;  2BDS A;  2K2X A;  1D6B A; 
#chains in the Genus database with same CATH topology
 1ATX A;  2HJE A;  1APF A;  2MN3 A;  3KEZ A;  2RNG A;  1WQK A;  1GL9 B;  3LMS B;  1ZUF A;  1AHL A;  4GV5 A;  1Z99 A;  3C38 A;  3IF4 A;  2SH1 A;  2DLA A;  1GKU B;  1ZHH B;  1WXN A;  1ZLH B;  2IKD A;  2JTO A;  2QSF A;  3D4U B;  3C30 A;  1ZUE A;  1SHI A;  2MUB A;  2QSG A;  2H9X A;  2IKE A;  1ZLI B;  2B9K A;  1BDS A;  1SH1 A;  2JR3 A;  1EL6 A;  3MYV A;  1H5O A;  2QSH A;  4YIR A;  3MCX A;  2BDS A;  2K2X A;  2XXL A;  1B8W A;  1D6B A;  2HJ9 C; 
#chains in the Genus database with same CATH homology
 1ATX A;  2HJE A;  1APF A;  2MN3 A;  3KEZ A;  2RNG A;  1WQK A;  3LMS B;  1ZUF A;  1AHL A;  4GV5 A;  1Z99 A;  3C38 A;  2SH1 A;  2DLA A;  1ZHH B;  1WXN A;  1ZLH B;  2IKD A;  2JTO A;  2QSF A;  3D4U B;  3C30 A;  1ZUE A;  1SHI A;  2MUB A;  2QSG A;  2H9X A;  2IKE A;  1ZLI B;  2B9K A;  1BDS A;  1SH1 A;  2JR3 A;  1H5O A;  3MYV A;  2QSH A;  4YIR A;  3MCX A;  2BDS A;  2K2X A;  2XXL A;  1B8W A;  1D6B A;  2HJ9 C; 
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similar chains in the Genus database (?% sequence similarity)
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similar chains in the pdb database (?% sequence similarity)

 
#similar chains in the Genus database (?% sequence similarity)
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#similar chains, but unknotted
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