4AMMA

Crystal structure of the acyltransferase domain of the iterative polyketide synthase in enediyne biosynthesis reveals the molecular basis of substrate specificity
Total Genus 130
Loading diagram...

The genus trace: a function that shows values of genus (vertical axis) for subchains spanned between the first residue, and all other residues (shown on horizontal axis). The number of the latter residue and the genus of a given subchain are shown interactively.

Total Genus
130
sequence length
401
structure length
384
Chain Sequence
PDHELVVCGAPDAAALTGLLTRVRAAATALSRPELTDLAAGLAAAHRGDVPARFAAAVRDADGLVAALDRALGHLAEGGRRLLDAGRGLFLVVGGPLRVGLLFPGQAAPVHADRGALGHKPAEPVDTAVAQPAIIADSLAGIRWLDRLGARPVGALGHSLGELAALSWAGALDADDTLALARARGEAMSAATEAPSGMLSLRADLAAARELAAGTGAVVAVDNGERHVVVAGTRPELDRVAEAARHAGIEATPLAVSHAFHSPLMAPAAEALRRAAGRLPWRRPERPVASTVTGAWWADEDPVEVLVRQLTGPVRFREALGLLDADLLVEVGPGRMLSALAEAAGRTAVSLDAGAASAAGMAAGTAALFAAGAVDDATPFFAGR
Loading diagram...

The genus matrix. At position (x,y) a genus value for a subchain spanned between x’th and y’th residue is shown. Values of the genus are represented by color, according to the scale given on the right.

Structure visualization

After clicking on a point (x,y) in the genus matrix above, a subchain from x to y is shown in color.

molecule tags Transferase
molecule keywords DYNE8
publication title Crystal Structure of the Acyltransferase Domain of the Iterative Polyketide Synthase in Enediyne Biosynthesis.
pubmed doi rcsb
source organism Micromonospora chersina
total genus 130
structure length 384
sequence length 401
ec nomenclature
pdb deposition date 2012-03-13

pfam database annotations

chain Pfam Accession Code Pfam Family Identifier Pfam Description
A PF00698 Acyl_transf_1 Acyl transferase domain
Image from the rcsb pdb (www.rcsb.org)
cath code
ClassArchitectureTopologyHomologyDomain
3.40.366.20 Alpha Beta 3-Layer(aba) Sandwich Malonyl-Coenzyme A Acyl Carrier Protein; domain 2 Malonyl-Coenzyme A Acyl Carrier Protein; domain 2 4ammA00
3TZXA 4AMNA 3TZZA 4AMPA 3TZYA 4AMOA 3TZWA 4AMMA
chains in the Genus database with same CATH superfamily
4RR5A 3HJVA 1NM2A 3SBMA 3HMJG 3PTWA 3TZWA 5CZDA 4AMOA 2PFFB 3HHDA 1MLAA 2G1HA 3G87A 2H1YA 3RGIA 3K89A 5CZCA 2G2OA 3EZOA 3R97A 2VKZG 4AMPA 3TZYA 2G2ZA 4AMMA 2G2YA 5DZ7A 2C2NA 3TZXA 2QC3A 2VZ9A 3TQEA 3IM9A 2QJ3A 2UV8G 2VZ8A 2QO3A 4AMNA 2CUYA 4RL1A 2JFDA 3QATA 2HG4A 3TZZA 5DZ6A 4QBUA 2JFKA 3H0PA 3IM8A
chains in the Genus database with same CATH topology
3TZXA 4AMNA 3TZZA 4AMPA 3TZYA 4AMOA 3TZWA 4AMMA
chains in the Genus database with same CATH homology


 
#chains in the Genus database with same CATH superfamily
 3TZX A;  4AMN A;  3TZZ A;  4AMP A;  3TZY A;  4AMO A;  3TZW A;  4AMM A; 
#chains in the Genus database with same CATH topology
 4RR5 A;  3HJV A;  1NM2 A;  3SBM A;  3HMJ G;  3PTW A;  3TZW A;  5CZD A;  4AMO A;  2PFF B;  3HHD A;  1MLA A;  2G1H A;  3G87 A;  2H1Y A;  3RGI A;  3K89 A;  5CZC A;  2G2O A;  3EZO A;  3R97 A;  2VKZ G;  4AMP A;  3TZY A;  2G2Z A;  4AMM A;  2G2Y A;  5DZ7 A;  2C2N A;  3TZX A;  2QC3 A;  2VZ9 A;  3TQE A;  3IM9 A;  2QJ3 A;  2UV8 G;  2VZ8 A;  2QO3 A;  4AMN A;  2CUY A;  4RL1 A;  2JFD A;  3QAT A;  2HG4 A;  3TZZ A;  5DZ6 A;  4QBU A;  2JFK A;  3H0P A;  3IM8 A; 
#chains in the Genus database with same CATH homology
 3TZX A;  4AMN A;  3TZZ A;  4AMP A;  3TZY A;  4AMO A;  3TZW A;  4AMM A; 
...loading similar chains, please wait...
similar chains in the Genus database (?% sequence similarity)
...loading similar chains, please wait...
similar chains in the pdb database (?% sequence similarity)

 
#similar chains in the Genus database (?% sequence similarity)
...loading similar chains, please wait...
#similar chains, but unknotted
...loading similar chains, please wait...
#similar chains in the pdb database (?% sequence similarity)
...loading similar chains, please wait...