4AMOA

Crystal structure of the acyltransferase domain of the iterative polyketide synthase in enediyne biosynthesis reveals the molecular basis of substrate specificity
Total Genus 124
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The genus trace: a function that shows values of genus (vertical axis) for subchains spanned between the first residue, and all other residues (shown on horizontal axis). The number of the latter residue and the genus of a given subchain are shown interactively.

Total Genus
124
sequence length
401
structure length
371
Chain Sequence
PDHELVVCGAPDAAALTGLLTRVRAAATALSRPELTDLAAGLAAAHRGDVPARFAAAVRDADGLVAALDRALGHLAEGGRRLLDAGRGLFLVVGGPLRVGLLFPGQAAPVPVDTAVAQPAIIADSLAGIRWLDRLGARPVGALGHSLGELAALSWAGALDADDTLALARARGEAMSVATEAPSGMLSLRADLAAARELAAGTGAVVAVDNGERHVVVAGTRPELDRVAEAARHAGIEATPLAVSHAFHSPLMAPAAEALRRAAGRLPWRRPERPVASTVTGAWWADEDPVEVLVRQLTGPVRFREALGLLDADLLVEVGPGRMLSALAEAAGRTAVSLDAGAASAAGMAAGTAALFAAGAVDDATPFFAGR
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The genus matrix. At position (x,y) a genus value for a subchain spanned between x’th and y’th residue is shown. Values of the genus are represented by color, according to the scale given on the right.

Structure visualization

After clicking on a point (x,y) in the genus matrix above, a subchain from x to y is shown in color.

molecule tags Transferase
molecule keywords DYNE8
publication title Crystal Structure of the Acyltransferase Domain of the Iterative Polyketide Synthase in Enediyne Biosynthesis.
pubmed doi rcsb
source organism Micromonospora chersina
total genus 124
structure length 371
sequence length 401
ec nomenclature
pdb deposition date 2012-03-13

pfam database annotations

chain Pfam Accession Code Pfam Family Identifier Pfam Description
A PF00698 Acyl_transf_1 Acyl transferase domain
Image from the rcsb pdb (www.rcsb.org)
cath code
ClassArchitectureTopologyHomologyDomain
3.40.366.20 Alpha Beta 3-Layer(aba) Sandwich Malonyl-Coenzyme A Acyl Carrier Protein; domain 2 Malonyl-Coenzyme A Acyl Carrier Protein; domain 2 4amoA00
3TZWA 4AMOA 4AMPA 4AMNA 3TZXA 3TZZA 4AMMA 3TZYA
chains in the Genus database with same CATH superfamily
3EZOA 2VZ9A 3TZWA 2H1YA 3K89A 5DZ6A 3IM9A 4AMOA 2PFFB 2G1HA 3SBMA 3HHDA 3IM8A 4AMPA 2VZ8A 3TZXA 3QATA 2HG4A 4RL1A 3TZYA 5CZCA 4RR5A 2VKZG 3HJVA 2G2ZA 2G2OA 2JFKA 1NM2A 2QJ3A 3TZZA 3H0PA 2C2NA 4AMMA 3G87A 1MLAA 2JFDA 3R97A 3RGIA 4QBUA 3HMJG 5CZDA 2QO3A 4AMNA 2UV8G 2QC3A 3PTWA 3TQEA 2CUYA 2G2YA 5DZ7A
chains in the Genus database with same CATH topology
3TZWA 4AMOA 4AMPA 4AMNA 3TZXA 3TZZA 4AMMA 3TZYA
chains in the Genus database with same CATH homology


 
#chains in the Genus database with same CATH superfamily
 3TZW A;  4AMO A;  4AMP A;  4AMN A;  3TZX A;  3TZZ A;  4AMM A;  3TZY A; 
#chains in the Genus database with same CATH topology
 3EZO A;  2VZ9 A;  3TZW A;  2H1Y A;  3K89 A;  5DZ6 A;  3IM9 A;  4AMO A;  2PFF B;  2G1H A;  3SBM A;  3HHD A;  3IM8 A;  4AMP A;  2VZ8 A;  3TZX A;  3QAT A;  2HG4 A;  4RL1 A;  3TZY A;  5CZC A;  4RR5 A;  2VKZ G;  3HJV A;  2G2Z A;  2G2O A;  2JFK A;  1NM2 A;  2QJ3 A;  3TZZ A;  3H0P A;  2C2N A;  4AMM A;  3G87 A;  1MLA A;  2JFD A;  3R97 A;  3RGI A;  4QBU A;  3HMJ G;  5CZD A;  2QO3 A;  4AMN A;  2UV8 G;  2QC3 A;  3PTW A;  3TQE A;  2CUY A;  2G2Y A;  5DZ7 A; 
#chains in the Genus database with same CATH homology
 3TZW A;  4AMO A;  4AMP A;  4AMN A;  3TZX A;  3TZZ A;  4AMM A;  3TZY A; 
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similar chains in the Genus database (?% sequence similarity)
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similar chains in the pdb database (?% sequence similarity)

 
#similar chains in the Genus database (?% sequence similarity)
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#similar chains, but unknotted
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#similar chains in the pdb database (?% sequence similarity)
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