4AMNA

Crystal structure of the acyltransferase domain of the iterative polyketide synthase in enediyne biosynthesis reveals the molecular basis of substrate specificity
Total Genus 126
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The genus trace: a function that shows values of genus (vertical axis) for subchains spanned between the first residue, and all other residues (shown on horizontal axis). The number of the latter residue and the genus of a given subchain are shown interactively.

Total Genus
126
sequence length
401
structure length
384
Chain Sequence
PDHELVVCGAPDAAALTGLLTRVRAAATALSRPELTDLAAGLAAAHRGDVPARFAAAVRDADGLVAALDRALGHLAEGGRRLLDAGRGLFLVVGGPLRVGLLFPGQAAPVHADRGALGHLPAEPVDTAVAQPAIIADSLAGIRWLDRLGARPVGALGHSLGELAALSWAGALDADDTLALARARGEAMSAATEAPSGMLSLRADLAAARELAAGTGAVVAVDNGERHVVVAGTRPELDRVAEAARHAGIEATPLAVSHAFHSPLMAPAAEALRRAAGRLPWRRPERPVASTVTGAWWADEDPVEVLVRQLTGPVRFREALGLLDADLLVEVGPGRMLSALAEAAGRTAVSLDAGAASAAGMAAGTAALFAAGAVDDATPFFAGR
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The genus matrix. At position (x,y) a genus value for a subchain spanned between x’th and y’th residue is shown. Values of the genus are represented by color, according to the scale given on the right.

Structure visualization

After clicking on a point (x,y) in the genus matrix above, a subchain from x to y is shown in color.

molecule tags Transferase
molecule keywords DYNE8
publication title Crystal Structure of the Acyltransferase Domain of the Iterative Polyketide Synthase in Enediyne Biosynthesis.
pubmed doi rcsb
source organism Micromonospora chersina
total genus 126
structure length 384
sequence length 401
ec nomenclature
pdb deposition date 2012-03-13

pfam database annotations

chain Pfam Accession Code Pfam Family Identifier Pfam Description
A PF00698 Acyl_transf_1 Acyl transferase domain
Image from the rcsb pdb (www.rcsb.org)
cath code
ClassArchitectureTopologyHomologyDomain
3.40.366.20 Alpha Beta 3-Layer(aba) Sandwich Malonyl-Coenzyme A Acyl Carrier Protein; domain 2 Malonyl-Coenzyme A Acyl Carrier Protein; domain 2 4amnA00
3TZXA 4AMMA 4AMOA 3TZYA 4AMPA 3TZZA 3TZWA 4AMNA
chains in the Genus database with same CATH superfamily
2CUYA 3RGIA 4AMMA 3HMJG 2G2YA 3TZYA 1NM2A 3TZZA 4QBUA 2QJ3A 2HG4A 2PFFB 3HJVA 3PTWA 2QO3A 4RL1A 2G2OA 4AMPA 2VKZG 3SBMA 3IM9A 3R97A 3TZWA 4RR5A 2VZ8A 3TZXA 2C2NA 1MLAA 3HHDA 2G1HA 5DZ7A 3G87A 4AMNA 2H1YA 3H0PA 2JFDA 2UV8G 3IM8A 4AMOA 2G2ZA 2VZ9A 5DZ6A 2QC3A 5CZDA 5CZCA 3TQEA 3EZOA 2JFKA 3K89A 3QATA
chains in the Genus database with same CATH topology
3TZXA 4AMMA 4AMOA 3TZYA 4AMPA 3TZZA 3TZWA 4AMNA
chains in the Genus database with same CATH homology


 
#chains in the Genus database with same CATH superfamily
 3TZX A;  4AMM A;  4AMO A;  3TZY A;  4AMP A;  3TZZ A;  3TZW A;  4AMN A; 
#chains in the Genus database with same CATH topology
 2CUY A;  3RGI A;  4AMM A;  3HMJ G;  2G2Y A;  3TZY A;  1NM2 A;  3TZZ A;  4QBU A;  2QJ3 A;  2HG4 A;  2PFF B;  3HJV A;  3PTW A;  2QO3 A;  4RL1 A;  2G2O A;  4AMP A;  2VKZ G;  3SBM A;  3IM9 A;  3R97 A;  3TZW A;  4RR5 A;  2VZ8 A;  3TZX A;  2C2N A;  1MLA A;  3HHD A;  2G1H A;  5DZ7 A;  3G87 A;  4AMN A;  2H1Y A;  3H0P A;  2JFD A;  2UV8 G;  3IM8 A;  4AMO A;  2G2Z A;  2VZ9 A;  5DZ6 A;  2QC3 A;  5CZD A;  5CZC A;  3TQE A;  3EZO A;  2JFK A;  3K89 A;  3QAT A; 
#chains in the Genus database with same CATH homology
 3TZX A;  4AMM A;  4AMO A;  3TZY A;  4AMP A;  3TZZ A;  3TZW A;  4AMN A; 
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similar chains in the Genus database (?% sequence similarity)
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similar chains in the pdb database (?% sequence similarity)

 
#similar chains in the Genus database (?% sequence similarity)
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#similar chains, but unknotted
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#similar chains in the pdb database (?% sequence similarity)
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