4AMPA

Crystal structure of the acyltransferase domain of the iterative polyketide synthase in enediyne biosynthesis reveals the molecular basis of substrate specificity
Total Genus 128
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The genus trace: a function that shows values of genus (vertical axis) for subchains spanned between the first residue, and all other residues (shown on horizontal axis). The number of the latter residue and the genus of a given subchain are shown interactively.

Total Genus
128
sequence length
401
structure length
372
Chain Sequence
PDHELVVCGAPDAAALTGLLTRVRAAATALSRPELTDLAAGLAAAHRGDVPARFAAAVRDADGLVAALDRALGHLAEGGRRLLDAGRGLFLVVGGPLRVGLLFPGQAAPVHPVDTAVAQPAIIADSLAGIRWLDRLGARPVGALGHSLGELAALSWAGALDADDTLALARARGEAMSAATEAPSGMLSLRADLAAARELAAGTGAVVAVDNGERHVVVAGTRPELDRVAEAARHAGIEATPLAVSHAFHSPLMAPAAEALRRAAGRLPWRRPERPVASTVTGAWWADEDPVEVLVRQLTGPVRFREALGLLDADLLVEVGPGRMLSALAEAAGRTAVSLDAGAASAAGMAAGTAALFAAGAVDDATPFFAGR
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The genus matrix. At position (x,y) a genus value for a subchain spanned between x’th and y’th residue is shown. Values of the genus are represented by color, according to the scale given on the right.

Structure visualization

After clicking on a point (x,y) in the genus matrix above, a subchain from x to y is shown in color.

molecule tags Transferase
molecule keywords DYNE8
publication title Crystal Structure of the Acyltransferase Domain of the Iterative Polyketide Synthase in Enediyne Biosynthesis.
pubmed doi rcsb
source organism Micromonospora chersina
total genus 128
structure length 372
sequence length 401
ec nomenclature
pdb deposition date 2012-03-13

pfam database annotations

chain Pfam Accession Code Pfam Family Identifier Pfam Description
A PF00698 Acyl_transf_1 Acyl transferase domain
Image from the rcsb pdb (www.rcsb.org)
cath code
ClassArchitectureTopologyHomologyDomain
3.40.366.20 Alpha Beta 3-Layer(aba) Sandwich Malonyl-Coenzyme A Acyl Carrier Protein; domain 2 Malonyl-Coenzyme A Acyl Carrier Protein; domain 2 4ampA00
4AMOA 4AMMA 3TZWA 3TZXA 3TZZA 3TZYA 4AMNA 4AMPA
chains in the Genus database with same CATH superfamily
3G87A 2CUYA 2C2NA 3R97A 4QBUA 3IM8A 2PFFB 2G2ZA 2G2YA 3QATA 5DZ7A 3TQEA 2UV8G 4AMPA 2QO3A 4AMOA 2VZ8A 3HMJG 2G1HA 1NM2A 3SBMA 5CZCA 3TZWA 3TZYA 3TZZA 4RR5A 1MLAA 5CZDA 3H0PA 2QJ3A 2VKZG 3HHDA 3RGIA 3K89A 4RL1A 2H1YA 3PTWA 3IM9A 2QC3A 3HJVA 3EZOA 2JFDA 2VZ9A 4AMMA 5DZ6A 3TZXA 2G2OA 4AMNA 2JFKA 2HG4A
chains in the Genus database with same CATH topology
4AMOA 4AMMA 3TZWA 3TZXA 3TZZA 3TZYA 4AMNA 4AMPA
chains in the Genus database with same CATH homology


 
#chains in the Genus database with same CATH superfamily
 4AMO A;  4AMM A;  3TZW A;  3TZX A;  3TZZ A;  3TZY A;  4AMN A;  4AMP A; 
#chains in the Genus database with same CATH topology
 3G87 A;  2CUY A;  2C2N A;  3R97 A;  4QBU A;  3IM8 A;  2PFF B;  2G2Z A;  2G2Y A;  3QAT A;  5DZ7 A;  3TQE A;  2UV8 G;  4AMP A;  2QO3 A;  4AMO A;  2VZ8 A;  3HMJ G;  2G1H A;  1NM2 A;  3SBM A;  5CZC A;  3TZW A;  3TZY A;  3TZZ A;  4RR5 A;  1MLA A;  5CZD A;  3H0P A;  2QJ3 A;  2VKZ G;  3HHD A;  3RGI A;  3K89 A;  4RL1 A;  2H1Y A;  3PTW A;  3IM9 A;  2QC3 A;  3HJV A;  3EZO A;  2JFD A;  2VZ9 A;  4AMM A;  5DZ6 A;  3TZX A;  2G2O A;  4AMN A;  2JFK A;  2HG4 A; 
#chains in the Genus database with same CATH homology
 4AMO A;  4AMM A;  3TZW A;  3TZX A;  3TZZ A;  3TZY A;  4AMN A;  4AMP A; 
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similar chains in the Genus database (?% sequence similarity)
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similar chains in the pdb database (?% sequence similarity)

 
#similar chains in the Genus database (?% sequence similarity)
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#similar chains, but unknotted
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#similar chains in the pdb database (?% sequence similarity)
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