4BVVA

Identification of small molecule inhibitors selective for apo(a) kringles kiv-7, kiv-10 and kv.
Total Genus 18
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The genus trace: a function that shows values of genus (vertical axis) for subchains spanned between the first residue, and all other residues (shown on horizontal axis). The number of the latter residue and the genus of a given subchain are shown interactively.

Total Genus
18
sequence length
81
structure length
81
Chain Sequence
DCMFGNGKGYRGKKATTVTGTPCQEWAAQEPHRHSTFIPGTNKWAGLEKNYCRNPDGDINGPWCYTMNPRKLFDYCDIPLC
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The genus matrix. At position (x,y) a genus value for a subchain spanned between x’th and y’th residue is shown. Values of the genus are represented by color, according to the scale given on the right.

Structure visualization

After clicking on a point (x,y) in the genus matrix above, a subchain from x to y is shown in color.

Chord Diagram
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molecule tags Hydrolase
molecule keywords APOLIPOPROTEIN(A)
publication title Small Molecules Used to Decipher the Pathophysiological Roles of the Kringle Domains Kiv-7, - 10 and Kv of Apolipoprotein(A)
rcsb
source organism Homo sapiens
total genus 18
structure length 81
sequence length 81
ec nomenclature ec 3.4.21.-:
pdb deposition date 2013-06-28

pfam database annotations

chain Pfam Accession Code Pfam Family Identifier Pfam Description
A PF00051 Kringle Kringle domain
Image from the rcsb pdb (www.rcsb.org)
cath code
ClassArchitectureTopologyHomologyDomain
2.40.20.10 Mainly Beta Beta Barrel Plasminogen Kringle 4 Plasminogen Kringle 4 4bvvA00
1HPKA 5CP9A 5CT2A 2I9AA 1CEAA 5CSQA 3KIVA 2HPPP 2K51A 1BHTA 5CS9A 4BVVA 2L0SA 4KIVA 1B2IA 4BVDA 1A0HA 1GP9A 3K65A 2FD6A 1KI0A 1TPKA 3NXPA 3BT2A 5CT3A 5HPGA 4BVWA 1NL1A 2KNFA 1PK2A 1URKA 5CS3A 2KJ4A 2DOIA 2I9BA 3HN4A 4BVCA 2HPQP 2PF2A 1GMNA 1GMOA 3LAQA 1KDUA 1JFNA 3U73A 2QJ2A 4BV7A 5CS1A 4BV5A 4D3CA 1I5KA 1KIVA 2K4RA 5COEA 3E6PL 4DURA 1I71A 1CEBA 2PF1A 2QJ4A 1NL2A 4CIKA 2DOHX 5CS5A 5CT1A 3BT1A 2FEBA 1PK4A 3MKPA 1NK1A 4O03A 1HPJA 3SP8A 4IUAA 4A5TS 2PK4A 2SPTA 1PMLA 4NZQA 1PMKA 1PKRA 4HZHA 1KRNA
chains in the Genus database with same CATH superfamily
1HPKA 5CP9A 5CT2A 2I9AA 1CEAA 5CSQA 3KIVA 2HPPP 2K51A 1BHTA 5CS9A 4BVVA 2L0SA 4KIVA 1B2IA 4BVDA 1A0HA 1GP9A 3K65A 2FD6A 1KI0A 1TPKA 3NXPA 3BT2A 5CT3A 5HPGA 4BVWA 1NL1A 2KNFA 1PK2A 1URKA 5CS3A 2KJ4A 2DOIA 2I9BA 3HN4A 4BVCA 2HPQP 2PF2A 1GMNA 1GMOA 3LAQA 1KDUA 1JFNA 3U73A 2QJ2A 4BV7A 5CS1A 4BV5A 4D3CA 1I5KA 1KIVA 2K4RA 5COEA 3E6PL 4DURA 1I71A 1CEBA 2PF1A 2QJ4A 1NL2A 4CIKA 2DOHX 5CS5A 5CT1A 3BT1A 2FEBA 1PK4A 3MKPA 1NK1A 4O03A 1HPJA 3SP8A 4IUAA 4A5TS 2PK4A 2SPTA 1PMLA 4NZQA 1PMKA 1PKRA 4HZHA 1KRNA
chains in the Genus database with same CATH topology
1HPKA 5CP9A 5CT2A 2I9AA 1CEAA 5CSQA 3KIVA 2HPPP 2K51A 1BHTA 5CS9A 4BVVA 2L0SA 4KIVA 1B2IA 4BVDA 1A0HA 1GP9A 3K65A 2FD6A 1KI0A 1TPKA 3NXPA 3BT2A 5CT3A 5HPGA 4BVWA 1NL1A 2KNFA 1PK2A 1URKA 5CS3A 2KJ4A 2DOIA 2I9BA 3HN4A 4BVCA 2HPQP 2PF2A 1GMNA 1GMOA 3LAQA 1KDUA 1JFNA 3U73A 2QJ2A 4BV7A 5CS1A 4BV5A 4D3CA 1I5KA 1KIVA 2K4RA 5COEA 3E6PL 4DURA 1I71A 1CEBA 2PF1A 2QJ4A 1NL2A 4CIKA 2DOHX 5CS5A 5CT1A 3BT1A 2FEBA 1PK4A 3MKPA 1NK1A 4O03A 1HPJA 3SP8A 4IUAA 4A5TS 2PK4A 2SPTA 1PMLA 4NZQA 1PMKA 1PKRA 4HZHA 1KRNA
chains in the Genus database with same CATH homology


 
#chains in the Genus database with same CATH superfamily
 1HPK A;  5CP9 A;  5CT2 A;  2I9A A;  1CEA A;  5CSQ A;  3KIV A;  2HPP P;  2K51 A;  1BHT A;  5CS9 A;  4BVV A;  2L0S A;  4KIV A;  1B2I A;  4BVD A;  1A0H A;  1GP9 A;  3K65 A;  2FD6 A;  1KI0 A;  1TPK A;  3NXP A;  3BT2 A;  5CT3 A;  5HPG A;  4BVW A;  1NL1 A;  2KNF A;  1PK2 A;  1URK A;  5CS3 A;  2KJ4 A;  2DOI A;  2I9B A;  3HN4 A;  4BVC A;  2HPQ P;  2PF2 A;  1GMN A;  1GMO A;  3LAQ A;  1KDU A;  1JFN A;  3U73 A;  2QJ2 A;  4BV7 A;  5CS1 A;  4BV5 A;  4D3C A;  1I5K A;  1KIV A;  2K4R A;  5COE A;  3E6P L;  4DUR A;  1I71 A;  1CEB A;  2PF1 A;  2QJ4 A;  1NL2 A;  4CIK A;  2DOH X;  5CS5 A;  5CT1 A;  3BT1 A;  2FEB A;  1PK4 A;  3MKP A;  1NK1 A;  4O03 A;  1HPJ A;  3SP8 A;  4IUA A;  4A5T S;  2PK4 A;  2SPT A;  1PML A;  4NZQ A;  1PMK A;  1PKR A;  4HZH A;  1KRN A; 
#chains in the Genus database with same CATH topology
 1HPK A;  5CP9 A;  5CT2 A;  2I9A A;  1CEA A;  5CSQ A;  3KIV A;  2HPP P;  2K51 A;  1BHT A;  5CS9 A;  4BVV A;  2L0S A;  4KIV A;  1B2I A;  4BVD A;  1A0H A;  1GP9 A;  3K65 A;  2FD6 A;  1KI0 A;  1TPK A;  3NXP A;  3BT2 A;  5CT3 A;  5HPG A;  4BVW A;  1NL1 A;  2KNF A;  1PK2 A;  1URK A;  5CS3 A;  2KJ4 A;  2DOI A;  2I9B A;  3HN4 A;  4BVC A;  2HPQ P;  2PF2 A;  1GMN A;  1GMO A;  3LAQ A;  1KDU A;  1JFN A;  3U73 A;  2QJ2 A;  4BV7 A;  5CS1 A;  4BV5 A;  4D3C A;  1I5K A;  1KIV A;  2K4R A;  5COE A;  3E6P L;  4DUR A;  1I71 A;  1CEB A;  2PF1 A;  2QJ4 A;  1NL2 A;  4CIK A;  2DOH X;  5CS5 A;  5CT1 A;  3BT1 A;  2FEB A;  1PK4 A;  3MKP A;  1NK1 A;  4O03 A;  1HPJ A;  3SP8 A;  4IUA A;  4A5T S;  2PK4 A;  2SPT A;  1PML A;  4NZQ A;  1PMK A;  1PKR A;  4HZH A;  1KRN A; 
#chains in the Genus database with same CATH homology
 1HPK A;  5CP9 A;  5CT2 A;  2I9A A;  1CEA A;  5CSQ A;  3KIV A;  2HPP P;  2K51 A;  1BHT A;  5CS9 A;  4BVV A;  2L0S A;  4KIV A;  1B2I A;  4BVD A;  1A0H A;  1GP9 A;  3K65 A;  2FD6 A;  1KI0 A;  1TPK A;  3NXP A;  3BT2 A;  5CT3 A;  5HPG A;  4BVW A;  1NL1 A;  2KNF A;  1PK2 A;  1URK A;  5CS3 A;  2KJ4 A;  2DOI A;  2I9B A;  3HN4 A;  4BVC A;  2HPQ P;  2PF2 A;  1GMN A;  1GMO A;  3LAQ A;  1KDU A;  1JFN A;  3U73 A;  2QJ2 A;  4BV7 A;  5CS1 A;  4BV5 A;  4D3C A;  1I5K A;  1KIV A;  2K4R A;  5COE A;  3E6P L;  4DUR A;  1I71 A;  1CEB A;  2PF1 A;  2QJ4 A;  1NL2 A;  4CIK A;  2DOH X;  5CS5 A;  5CT1 A;  3BT1 A;  2FEB A;  1PK4 A;  3MKP A;  1NK1 A;  4O03 A;  1HPJ A;  3SP8 A;  4IUA A;  4A5T S;  2PK4 A;  2SPT A;  1PML A;  4NZQ A;  1PMK A;  1PKR A;  4HZH A;  1KRN A; 
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similar chains in the Genus database (?% sequence similarity)
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similar chains in the pdb database (?% sequence similarity)

 
#similar chains in the Genus database (?% sequence similarity)
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#similar chains, but unknotted
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