1GMNA

Crystal structures of nk1-heparin complexes reveal the basis for nk1 activity and enable engineering of potent agonists of the met receptor
Total Genus 39
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The genus trace: a function that shows values of genus (vertical axis) for subchains spanned between the first residue, and all other residues (shown on horizontal axis). The number of the latter residue and the genus of a given subchain are shown interactively.

Total Genus
39
sequence length
170
structure length
170
Chain Sequence
TIHEFKKSAKTTLIKIDPALKIKTKKVNTADQCADRCTRNKGLPFTCKAFVFDKARKQCLWFPFNSMSSGVKKEFGHEFDLYENKDYIRNCIIGKGRSYKGTVSITKSGIKCQPWSSMIPHEHSFLPSSYRGKDLQENYCRNPRGEEGGPWCFTSNPEVRYEVCDIPQCS
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The genus matrix. At position (x,y) a genus value for a subchain spanned between x’th and y’th residue is shown. Values of the genus are represented by color, according to the scale given on the right.

Structure visualization

After clicking on a point (x,y) in the genus matrix above, a subchain from x to y is shown in color.

Chord Diagram
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molecule tags Hormone/growth factor
molecule keywords HEPATOCYTE GROWTH FACTOR
publication title Crystal Structures of Nk1-Heparin Complexes Reveal the Basis for Nk1 Activity and Enable Engineering of Potent Agonists of the met Receptor
pubmed doi rcsb
source organism Homo sapiens
total genus 39
structure length 170
sequence length 170
chains with identical sequence B
ec nomenclature
pdb deposition date 2001-09-19

pfam database annotations

chain Pfam Accession Code Pfam Family Identifier Pfam Description
A PF00024 PAN_1 PAN domain
A PF00051 Kringle Kringle domain
Image from the rcsb pdb (www.rcsb.org)
cath code
ClassArchitectureTopologyHomologyDomain
2.40.20.10 Mainly Beta Beta Barrel Plasminogen Kringle 4 Plasminogen Kringle 4 1gmnA02
3.50.4.10 Alpha Beta 3-Layer(bba) Sandwich Hepatocyte Growth Factor Hepatocyte Growth Factor 1gmnA01
1NL1A 4Z0EA 4UAOA 1PMKA 5COEA 2KJ4A 4BV5A 2J8LA 1HPJA 5CS1A 2HPQP 2SPTA 3U73A 4D3CA 2QJ4A 1KI0A 4NZQA 4APLA 5EOKA 5CSQA 1PKRA 4HZHA 5CS3A 1PMLA 3SRJA 4BVCA 1NK1A 3HMSA 2F83A 3NXPA 3ZLEA 2Q8BA 4CIKA 4Z09A 1GMOA 4R1BA 3HN4A 2FD6A 2X2ZA 1W8KA 2YILA 4Z0FA 2KNFA 5CT3A 1Z40A 3HMTA 1URKA 4BV7A 2DOHX 2QJ2A 1KIVA 2Z8VA 1PK4A 3K65A 3ZWZA 1GP9A 1TPKA 2K4RA 2LL4M 3BT1A 2K13X 1KDUA 2LL3A 4Z0DA 1NL2A 3KIVA 4R1CA 4DURA 4O03A 4BVDA 4UV6A 1W81A 5CT2A 4IUAA 2K51A 2YIOA 4R1AA 5CS5A 1BHTA 2PF2A 5CS9A 2YIPA 5EODA 2DOIA 2PF1A 5CP9A 3HMRA 1HKYA 2Y8RA 2I9BA 5CT1A 2J8JA 2I9AA 2HGFA 4A5TS 2Z8WA 4BVWA 4APMA 3MKPA 2Q8AA 4KIVA 1I8NA 1I5KA 1I71A 2L0SA 3E6PL 3SP8A 5I25A 1HPKA 3SRIA 2FEBA 2PK4A 4BVVA 4R19A 1CEAA 3BT2A 1A0HA 1CEBA 1KRNA 1PK2A 1YXEA 2HPPP 5HPGA 1B2IA 1GMNA 1JFNA 3LAQA
chains in the Genus database with same CATH superfamily
1NL1A 4Z0EA 4UAOA 1PMKA 5COEA 2KJ4A 4BV5A 2J8LA 1HPJA 5CS1A 2HPQP 2SPTA 3U73A 4D3CA 2QJ4A 1KI0A 4NZQA 4APLA 5EOKA 5CSQA 1PKRA 4HZHA 5CS3A 1PMLA 3SRJA 4BVCA 1NK1A 3HMSA 2F83A 3NXPA 3ZLEA 2Q8BA 4CIKA 4Z09A 1GMOA 4R1BA 3HN4A 2FD6A 2X2ZA 1W8KA 2YILA 4Z0FA 2KNFA 5CT3A 1Z40A 3HMTA 1URKA 4BV7A 2DOHX 2QJ2A 1KIVA 2Z8VA 1PK4A 3K65A 3ZWZA 1GP9A 1TPKA 2K4RA 2LL4M 3BT1A 2K13X 1KDUA 2LL3A 4Z0DA 1NL2A 3KIVA 4R1CA 4DURA 4O03A 4BVDA 4UV6A 1W81A 5CT2A 4IUAA 2K51A 2YIOA 4R1AA 5CS5A 1BHTA 2PF2A 5CS9A 2YIPA 5EODA 2DOIA 2PF1A 5CP9A 3HMRA 1HKYA 2Y8RA 2I9BA 5CT1A 4YIVA 2J8JA 2I9AA 2HGFA 4A5TS 2Z8WA 4BVWA 4APMA 3MKPA 2Q8AA 2KL5A 4KIVA 1I8NA 1I5KA 1I71A 2L0SA 4YIZA 3E6PL 3SP8A 5I25A 1HPKA 3SRIA 2FEBA 2PK4A 4BVVA 4R19A 1CEAA 3BT2A 1A0HA 1CEBA 1KRNA 1PK2A 1YXEA 2HPPP 5HPGA 1B2IA 1GMNA 1JFNA 3LAQA
chains in the Genus database with same CATH topology
1NL1A 4Z0EA 4UAOA 1PMKA 5COEA 2KJ4A 4BV5A 2J8LA 1HPJA 5CS1A 2HPQP 2SPTA 3U73A 4D3CA 2QJ4A 1KI0A 4NZQA 4APLA 5EOKA 5CSQA 1PKRA 4HZHA 5CS3A 1PMLA 3SRJA 4BVCA 1NK1A 3HMSA 2F83A 3NXPA 3ZLEA 2Q8BA 4CIKA 4Z09A 1GMOA 4R1BA 3HN4A 2FD6A 2X2ZA 1W8KA 2YILA 4Z0FA 2KNFA 5CT3A 1Z40A 3HMTA 1URKA 4BV7A 2DOHX 2QJ2A 1KIVA 2Z8VA 1PK4A 3K65A 3ZWZA 1GP9A 1TPKA 2K4RA 2LL4M 3BT1A 2K13X 1KDUA 2LL3A 4Z0DA 1NL2A 3KIVA 4R1CA 4DURA 4O03A 4BVDA 4UV6A 1W81A 5CT2A 4IUAA 2K51A 2YIOA 4R1AA 5CS5A 1BHTA 2PF2A 5CS9A 2YIPA 5EODA 2DOIA 2PF1A 5CP9A 3HMRA 1HKYA 2Y8RA 2I9BA 5CT1A 4YIVA 2J8JA 2I9AA 2HGFA 4A5TS 2Z8WA 4BVWA 4APMA 3MKPA 2Q8AA 2KL5A 4KIVA 1I8NA 1I5KA 1I71A 2L0SA 4YIZA 3E6PL 3SP8A 5I25A 1HPKA 3SRIA 2FEBA 2PK4A 4BVVA 4R19A 1CEAA 3BT2A 1A0HA 1CEBA 1KRNA 1PK2A 1YXEA 2HPPP 5HPGA 1B2IA 1GMNA 1JFNA 3LAQA
chains in the Genus database with same CATH homology


 
#chains in the Genus database with same CATH superfamily
 1NL1 A;  4Z0E A;  4UAO A;  1PMK A;  5COE A;  2KJ4 A;  4BV5 A;  2J8L A;  1HPJ A;  5CS1 A;  2HPQ P;  2SPT A;  3U73 A;  4D3C A;  2QJ4 A;  1KI0 A;  4NZQ A;  4APL A;  5EOK A;  5CSQ A;  1PKR A;  4HZH A;  5CS3 A;  1PML A;  3SRJ A;  4BVC A;  1NK1 A;  3HMS A;  2F83 A;  3NXP A;  3ZLE A;  2Q8B A;  4CIK A;  4Z09 A;  1GMO A;  4R1B A;  3HN4 A;  2FD6 A;  2X2Z A;  1W8K A;  2YIL A;  4Z0F A;  2KNF A;  5CT3 A;  1Z40 A;  3HMT A;  1URK A;  4BV7 A;  2DOH X;  2QJ2 A;  1KIV A;  2Z8V A;  1PK4 A;  3K65 A;  3ZWZ A;  1GP9 A;  1TPK A;  2K4R A;  2LL4 M;  3BT1 A;  2K13 X;  1KDU A;  2LL3 A;  4Z0D A;  1NL2 A;  3KIV A;  4R1C A;  4DUR A;  4O03 A;  4BVD A;  4UV6 A;  1W81 A;  5CT2 A;  4IUA A;  2K51 A;  2YIO A;  4R1A A;  5CS5 A;  1BHT A;  2PF2 A;  5CS9 A;  2YIP A;  5EOD A;  2DOI A;  2PF1 A;  5CP9 A;  3HMR A;  1HKY A;  2Y8R A;  2I9B A;  5CT1 A;  2J8J A;  2I9A A;  2HGF A;  4A5T S;  2Z8W A;  4BVW A;  4APM A;  3MKP A;  2Q8A A;  4KIV A;  1I8N A;  1I5K A;  1I71 A;  2L0S A;  3E6P L;  3SP8 A;  5I25 A;  1HPK A;  3SRI A;  2FEB A;  2PK4 A;  4BVV A;  4R19 A;  1CEA A;  3BT2 A;  1A0H A;  1CEB A;  1KRN A;  1PK2 A;  1YXE A;  2HPP P;  5HPG A;  1B2I A;  1GMN A;  1JFN A;  3LAQ A; 
#chains in the Genus database with same CATH topology
 1NL1 A;  4Z0E A;  4UAO A;  1PMK A;  5COE A;  2KJ4 A;  4BV5 A;  2J8L A;  1HPJ A;  5CS1 A;  2HPQ P;  2SPT A;  3U73 A;  4D3C A;  2QJ4 A;  1KI0 A;  4NZQ A;  4APL A;  5EOK A;  5CSQ A;  1PKR A;  4HZH A;  5CS3 A;  1PML A;  3SRJ A;  4BVC A;  1NK1 A;  3HMS A;  2F83 A;  3NXP A;  3ZLE A;  2Q8B A;  4CIK A;  4Z09 A;  1GMO A;  4R1B A;  3HN4 A;  2FD6 A;  2X2Z A;  1W8K A;  2YIL A;  4Z0F A;  2KNF A;  5CT3 A;  1Z40 A;  3HMT A;  1URK A;  4BV7 A;  2DOH X;  2QJ2 A;  1KIV A;  2Z8V A;  1PK4 A;  3K65 A;  3ZWZ A;  1GP9 A;  1TPK A;  2K4R A;  2LL4 M;  3BT1 A;  2K13 X;  1KDU A;  2LL3 A;  4Z0D A;  1NL2 A;  3KIV A;  4R1C A;  4DUR A;  4O03 A;  4BVD A;  4UV6 A;  1W81 A;  5CT2 A;  4IUA A;  2K51 A;  2YIO A;  4R1A A;  5CS5 A;  1BHT A;  2PF2 A;  5CS9 A;  2YIP A;  5EOD A;  2DOI A;  2PF1 A;  5CP9 A;  3HMR A;  1HKY A;  2Y8R A;  2I9B A;  5CT1 A;  4YIV A;  2J8J A;  2I9A A;  2HGF A;  4A5T S;  2Z8W A;  4BVW A;  4APM A;  3MKP A;  2Q8A A;  2KL5 A;  4KIV A;  1I8N A;  1I5K A;  1I71 A;  2L0S A;  4YIZ A;  3E6P L;  3SP8 A;  5I25 A;  1HPK A;  3SRI A;  2FEB A;  2PK4 A;  4BVV A;  4R19 A;  1CEA A;  3BT2 A;  1A0H A;  1CEB A;  1KRN A;  1PK2 A;  1YXE A;  2HPP P;  5HPG A;  1B2I A;  1GMN A;  1JFN A;  3LAQ A; 
#chains in the Genus database with same CATH homology
 1NL1 A;  4Z0E A;  4UAO A;  1PMK A;  5COE A;  2KJ4 A;  4BV5 A;  2J8L A;  1HPJ A;  5CS1 A;  2HPQ P;  2SPT A;  3U73 A;  4D3C A;  2QJ4 A;  1KI0 A;  4NZQ A;  4APL A;  5EOK A;  5CSQ A;  1PKR A;  4HZH A;  5CS3 A;  1PML A;  3SRJ A;  4BVC A;  1NK1 A;  3HMS A;  2F83 A;  3NXP A;  3ZLE A;  2Q8B A;  4CIK A;  4Z09 A;  1GMO A;  4R1B A;  3HN4 A;  2FD6 A;  2X2Z A;  1W8K A;  2YIL A;  4Z0F A;  2KNF A;  5CT3 A;  1Z40 A;  3HMT A;  1URK A;  4BV7 A;  2DOH X;  2QJ2 A;  1KIV A;  2Z8V A;  1PK4 A;  3K65 A;  3ZWZ A;  1GP9 A;  1TPK A;  2K4R A;  2LL4 M;  3BT1 A;  2K13 X;  1KDU A;  2LL3 A;  4Z0D A;  1NL2 A;  3KIV A;  4R1C A;  4DUR A;  4O03 A;  4BVD A;  4UV6 A;  1W81 A;  5CT2 A;  4IUA A;  2K51 A;  2YIO A;  4R1A A;  5CS5 A;  1BHT A;  2PF2 A;  5CS9 A;  2YIP A;  5EOD A;  2DOI A;  2PF1 A;  5CP9 A;  3HMR A;  1HKY A;  2Y8R A;  2I9B A;  5CT1 A;  4YIV A;  2J8J A;  2I9A A;  2HGF A;  4A5T S;  2Z8W A;  4BVW A;  4APM A;  3MKP A;  2Q8A A;  2KL5 A;  4KIV A;  1I8N A;  1I5K A;  1I71 A;  2L0S A;  4YIZ A;  3E6P L;  3SP8 A;  5I25 A;  1HPK A;  3SRI A;  2FEB A;  2PK4 A;  4BVV A;  4R19 A;  1CEA A;  3BT2 A;  1A0H A;  1CEB A;  1KRN A;  1PK2 A;  1YXE A;  2HPP P;  5HPG A;  1B2I A;  1GMN A;  1JFN A;  3LAQ A; 
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similar chains in the Genus database (?% sequence similarity)
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similar chains in the pdb database (?% sequence similarity)

 
#similar chains in the Genus database (?% sequence similarity)
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#similar chains, but unknotted
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