4E44B

Crystal structure of the hmhf1/hmhf2 histone-fold tetramer
Total Genus 26
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The genus trace: a function that shows values of genus (vertical axis) for subchains spanned between the first residue, and all other residues (shown on horizontal axis). The number of the latter residue and the genus of a given subchain are shown interactively.

Total Genus
26
sequence length
75
structure length
75
Chain Sequence
GSGFRKELVSRLLHLHFKDDKTKVSGDALQLMVELLKVFVVEAAVRGVRQAQAEDALRVDVDQLEKVLPQLLLDF
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The genus matrix. At position (x,y) a genus value for a subchain spanned between x’th and y’th residue is shown. Values of the genus are represented by color, according to the scale given on the right.

Structure visualization

After clicking on a point (x,y) in the genus matrix above, a subchain from x to y is shown in color.

Chord Diagram
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molecule tags Dna binding protein
molecule keywords Centromere protein S
publication title Crystal Structures Reveal that FANCM remodels the MHF Tetramer in favor of binding Branched DNA
rcsb
source organism Homo sapiens
total genus 26
structure length 75
sequence length 75
chains with identical sequence D
ec nomenclature
pdb deposition date 2012-03-12

pfam database annotations

chain Pfam Accession Code Pfam Family Identifier Pfam Description
B PF09415 CENP-X CENP-S associating Centromere protein X
Image from the rcsb pdb (www.rcsb.org)
cath code
ClassArchitectureTopologyHomologyDomain
1.10.286.100 Mainly Alpha Orthogonal Bundle GTP Cyclohydrolase I; Chain A, domain 1 GTP Cyclohydrolase I; Chain A, domain 1 4e44B02
4NE6B 4DRAE 4NE3B 3B0BC 4E44B 4DRBJ 4NE5B 4E45B
chains in the Genus database with same CATH superfamily
4NE6B 1EFUB 4R8QA 1A8RA 1GTPA 2O01G 4DU6A 1WPLA 4DRBJ 4NE5B 3VEJA 1AIPC 1EL6A 1WURA 2WSEK 1WM9A 2KR1A 1FBXA 2WSEG 4E45B 4JA3A 1FB1A 1A9CA 4NE3B 2LNZA 4Q7JA 2P11A 4E44B 1IS7A 5DMZA 1WUQA 2PN0A 2WSFK 3LW5K 4QPMA 4DRAE 1N3SA 2WSCK 1IS8A 1N3RA 3B0BC 1N3TA 2WSFG 3LW5G 2WSCG 2LO0A 3BMBA 1TFEA
chains in the Genus database with same CATH topology
4NE6B 1EFUB 4R8QA 1A8RA 1GTPA 4DU6A 1WPLA 4DRBJ 4NE5B 3VEJA 1AIPC 1EL6A 1WURA 1WM9A 2KR1A 1FBXA 4E45B 4JA3A 1FB1A 1A9CA 4NE3B 2LNZA 4Q7JA 2P11A 4E44B 1IS7A 5DMZA 1WUQA 2PN0A 4QPMA 4DRAE 1N3SA 1IS8A 1N3RA 3B0BC 1N3TA 2LO0A 3BMBA 1TFEA
chains in the Genus database with same CATH homology


 
#chains in the Genus database with same CATH superfamily
 4NE6 B;  4DRA E;  4NE3 B;  3B0B C;  4E44 B;  4DRB J;  4NE5 B;  4E45 B; 
#chains in the Genus database with same CATH topology
 4NE6 B;  1EFU B;  4R8Q A;  1A8R A;  1GTP A;  2O01 G;  4DU6 A;  1WPL A;  4DRB J;  4NE5 B;  3VEJ A;  1AIP C;  1EL6 A;  1WUR A;  2WSE K;  1WM9 A;  2KR1 A;  1FBX A;  2WSE G;  4E45 B;  4JA3 A;  1FB1 A;  1A9C A;  4NE3 B;  2LNZ A;  4Q7J A;  2P11 A;  4E44 B;  1IS7 A;  5DMZ A;  1WUQ A;  2PN0 A;  2WSF K;  3LW5 K;  4QPM A;  4DRA E;  1N3S A;  2WSC K;  1IS8 A;  1N3R A;  3B0B C;  1N3T A;  2WSF G;  3LW5 G;  2WSC G;  2LO0 A;  3BMB A;  1TFE A; 
#chains in the Genus database with same CATH homology
 4NE6 B;  1EFU B;  4R8Q A;  1A8R A;  1GTP A;  4DU6 A;  1WPL A;  4DRB J;  4NE5 B;  3VEJ A;  1AIP C;  1EL6 A;  1WUR A;  1WM9 A;  2KR1 A;  1FBX A;  4E45 B;  4JA3 A;  1FB1 A;  1A9C A;  4NE3 B;  2LNZ A;  4Q7J A;  2P11 A;  4E44 B;  1IS7 A;  5DMZ A;  1WUQ A;  2PN0 A;  4QPM A;  4DRA E;  1N3S A;  1IS8 A;  1N3R A;  3B0B C;  1N3T A;  2LO0 A;  3BMB A;  1TFE A; 
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similar chains in the Genus database (?% sequence similarity)
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similar chains in the pdb database (?% sequence similarity)

 
#similar chains in the Genus database (?% sequence similarity)
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#similar chains, but unknotted
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